Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus

Emmanuel Roilides; Caron A. Lyman; Joanna Filioti; Onome Akpogheneta; Tin Sein; Cristina Gil Lamaignere; Ruta Petraitiene; Thomas J. Walsh

doi:10.1128/AAC.46.6.1974-1976.2002

Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus

Emmanuel Roilides
, Caron A. Lyman
, Joanna Filioti
, Onome Akpogheneta
, Tin Sein
, Cristina Gil Lamaignere
, Ruta Petraitiene
, Thomas J. Walsh

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.

Original language	English (US)
Pages (from-to)	1974-1976
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	46
Issue number	6
DOIs	https://doi.org/10.1128/AAC.46.6.1974-1976.2002
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.46.6.1974-1976.2002

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Roilides, E., Lyman, C. A., Filioti, J., Akpogheneta, O., Sein, T., Lamaignere, C. G., Petraitiene, R., & Walsh, T. J. (2002). Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus. Antimicrobial agents and chemotherapy, 46(6), 1974-1976. https://doi.org/10.1128/AAC.46.6.1974-1976.2002

Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus. / Roilides, Emmanuel; Lyman, Caron A.; Filioti, Joanna et al.
In: Antimicrobial agents and chemotherapy, Vol. 46, No. 6, 2002, p. 1974-1976.

Research output: Contribution to journal › Article › peer-review

Roilides, E, Lyman, CA, Filioti, J, Akpogheneta, O, Sein, T, Lamaignere, CG, Petraitiene, R & Walsh, TJ 2002, 'Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus', Antimicrobial agents and chemotherapy, vol. 46, no. 6, pp. 1974-1976. https://doi.org/10.1128/AAC.46.6.1974-1976.2002

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abstract = "Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.",

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AU - Sein, Tin

AU - Lamaignere, Cristina Gil

AU - Petraitiene, Ruta

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AB - Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.

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Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus

Abstract

ASJC Scopus subject areas

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