Amphibian Renal Disease

Christine Parker-Graham, Leigh A. Clayton, Lisa M. Mangus

Research output: Contribution to journalReview articlepeer-review


Amphibians are a remarkably diverse group of vertebrates with lifestyles ranging from fully aquatic to entirely terrestrial. Although some aspects of renal anatomy and physiology are similar among all amphibians, species differences in nitrogenous waste production and broad normal variation in plasma osmolality and composition make definitive antemortem diagnosis of renal disease challenging. Treatment is often empirical and aimed at addressing possible underlying infection, reducing abnormal fluid accumulation, and optimizing husbandry practices to support metabolic and fluid homeostasis. This article reviews amphibian renal anatomy and physiology, provides recommendations for diagnostic and therapeutic options, and discusses etiologies of renal disease.

Original languageEnglish (US)
Pages (from-to)215-230
Number of pages16
JournalVeterinary Clinics of North America - Exotic Animal Practice
Issue number1
StatePublished - Jan 2020


  • Amphibian
  • Infectious disease
  • Kidney
  • Neoplasia
  • Pathology
  • Physiology
  • Renal
  • Therapy

ASJC Scopus subject areas

  • Small Animals


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