Amphetamine neurotoxicity: Accomplishments and remaining challenges

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117 Scopus citations


In addition to the social, cultural and indirect medical complications of amphetamine analog abuse, this class of drugs is also known to have the potential to damage brain monoaminergic cells directly. Using methamphetamine as a prototype, this article provides a brief review of the history of amphetamine neurotoxicity research and the progress that has been made toward defining its characteristics. Remaining challenges for this line of investigation are outlined, and suggested avenues for addressing these challenges are provided.

Original languageEnglish (US)
Pages (from-to)821-826
Number of pages6
JournalNeuroscience and Biobehavioral Reviews
Issue number8
StatePublished - Jan 2004


  • Dopamine
  • Drug abuse
  • MDMA
  • Methamphetamine
  • Monoamines
  • Serotonin

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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