Abstract
Long-lasting depletion of dopamine and concomitant loss of dopamine uptake sites follow repeated administration of methylamphetamine to rats. We found similar effects after similar treatment with d-amphetamine, but not after treatment with methyl-phenidate. Methylphenidate also failed to produce long-term depletion of regional catecholamine levels in rhesus monkeys. These long-lasting alterations of the dopaminergic system suggest that amphetamines or their metabolites have toxic interactions with dopaminergic neurons, which do not occur with methylphenidate.
Original language | English (US) |
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Pages (from-to) | 547-550 |
Number of pages | 4 |
Journal | Neurology |
Volume | 30 |
Issue number | 5 |
DOIs | |
State | Published - May 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology