AMPARs and synaptic plasticity: The last 25 years

Richard L. Huganir, Roger A. Nicoll

Research output: Contribution to journalReview articlepeer-review

531 Scopus citations


The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas of research in neuroscience. In the last 25 years we have come a long way in our understanding of the mechanisms underlying synaptic plasticity. In 1988, AMPA and NMDA receptors were not even molecularly identified and we only had a simple model of the minimal requirements for the induction of plasticity. It is now clear that the modulation of the AMPA receptor function and membrane trafficking is critical for many forms of synaptic plasticity and a large number of proteins have been identified that regulate this complex process. Here we review the progress over the last two and a half decades and discuss the future challenges in the field

Original languageEnglish (US)
Pages (from-to)704-717
Number of pages14
Issue number3
StatePublished - Oct 30 2013

ASJC Scopus subject areas

  • Neuroscience(all)


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