AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

George Umanah; Mehdi Ghasemi; Xiling Yin; Melissa Chang; Jin Wan Kim; Jianmin Zhang; Erica Ma; Leslie A. Scarffe; Yun Il Lee; Rong Chen; Kavya Tangella; Amy McNamara; Leire Abalde-Atristain; Mohamad A. Dar; Samuel Bennett; Marisol Cortes; Shaida A Andrabi; Paschalis Thomas Doulias; Harry Ischiropoulos; Ted M. Dawson; Valina L. Dawson

doi:10.1016/j.celrep.2020.108329

AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

George Umanah, Mehdi Ghasemi, Xiling Yin, Melissa Chang, Jin Wan Kim, Jianmin Zhang, Erica Ma, Leslie A. Scarffe, Yun Il Lee, Rong Chen, Kavya Tangella, Amy McNamara, Leire Abalde-Atristain, Mohamad A. Dar, Samuel Bennett, Marisol Cortes, Shaida A Andrabi, Paschalis Thomas Doulias, Harry Ischiropoulos, Ted M. DawsonValina L. Dawson

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Umanah et al. show that the S-nitrosylation of Thorase and the transnitrosylation of NSF are responsible for NMDAR-activated trafficking of AMPARs underlying synaptic plasticity.

Original language	English (US)
Article number	108329
Journal	Cell Reports
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.108329
State	Published - Nov 3 2020

Keywords

AMPAR
ATAD1
GluA2
N-ethylmaleimide-sensitive factor
N-methyl-D-aspartate receptor
NMDAR
NSF
PICK1
S-nitrosylation
endocytosis
exocytosis
protein-interacting C kinase 1
thorase
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108329

Cite this

Umanah, G., Ghasemi, M., Yin, X., Chang, M., Kim, J. W., Zhang, J., Ma, E., Scarffe, L. A., Lee, Y. I., Chen, R., Tangella, K., McNamara, A., Abalde-Atristain, L., Dar, M. A., Bennett, S., Cortes, M., Andrabi, S. A., Doulias, P. T., Ischiropoulos, H., ... Dawson, V. L. (2020). AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF. Cell Reports, 33(5), Article 108329. https://doi.org/10.1016/j.celrep.2020.108329

Umanah, G, Ghasemi, M, Yin, X, Chang, M, Kim, JW, Zhang, J, Ma, E, Scarffe, LA, Lee, YI, Chen, R, Tangella, K, McNamara, A, Abalde-Atristain, L, Dar, MA, Bennett, S, Cortes, M, Andrabi, SA, Doulias, PT, Ischiropoulos, H, Dawson, TM & Dawson, VL 2020, 'AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF', Cell Reports, vol. 33, no. 5, 108329. https://doi.org/10.1016/j.celrep.2020.108329

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title = "AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF",

abstract = "Umanah et al. show that the S-nitrosylation of Thorase and the transnitrosylation of NSF are responsible for NMDAR-activated trafficking of AMPARs underlying synaptic plasticity.",

keywords = "AMPAR, ATAD1, GluA2, N-ethylmaleimide-sensitive factor, N-methyl-D-aspartate receptor, NMDAR, NSF, PICK1, S-nitrosylation, endocytosis, exocytosis, protein-interacting C kinase 1, thorase, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor",

author = "George Umanah and Mehdi Ghasemi and Xiling Yin and Melissa Chang and Kim, {Jin Wan} and Jianmin Zhang and Erica Ma and Scarffe, {Leslie A.} and Lee, {Yun Il} and Rong Chen and Kavya Tangella and Amy McNamara and Leire Abalde-Atristain and Dar, {Mohamad A.} and Samuel Bennett and Marisol Cortes and Andrabi, {Shaida A} and Doulias, {Paschalis Thomas} and Harry Ischiropoulos and Dawson, {Ted M.} and Dawson, {Valina L.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = nov,

day = "3",

doi = "10.1016/j.celrep.2020.108329",

language = "English (US)",

volume = "33",

journal = "Cell Reports",

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AU - Umanah, George

AU - Ghasemi, Mehdi

AU - Yin, Xiling

AU - Chang, Melissa

AU - Kim, Jin Wan

AU - Zhang, Jianmin

AU - Ma, Erica

AU - Scarffe, Leslie A.

AU - Lee, Yun Il

AU - Chen, Rong

AU - Tangella, Kavya

AU - McNamara, Amy

AU - Abalde-Atristain, Leire

AU - Dar, Mohamad A.

AU - Bennett, Samuel

AU - Cortes, Marisol

AU - Andrabi, Shaida A

AU - Doulias, Paschalis Thomas

AU - Ischiropoulos, Harry

AU - Dawson, Ted M.

AU - Dawson, Valina L.

PY - 2020/11/3

Y1 - 2020/11/3

N2 - Umanah et al. show that the S-nitrosylation of Thorase and the transnitrosylation of NSF are responsible for NMDAR-activated trafficking of AMPARs underlying synaptic plasticity.

AB - Umanah et al. show that the S-nitrosylation of Thorase and the transnitrosylation of NSF are responsible for NMDAR-activated trafficking of AMPARs underlying synaptic plasticity.

KW - AMPAR

KW - ATAD1

KW - GluA2

KW - N-ethylmaleimide-sensitive factor

KW - N-methyl-D-aspartate receptor

KW - NMDAR

KW - NSF

KW - PICK1

KW - S-nitrosylation

KW - endocytosis

KW - exocytosis

KW - protein-interacting C kinase 1

KW - thorase

KW - α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

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JO - Cell Reports

JF - Cell Reports

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ER -

AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

Abstract

Keywords

ASJC Scopus subject areas

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