Amodiaquine Ocular Changes

Lawrence W. Hirst; George Sanborn; W. Richard Green; Neil R. Miller; William D. Heath

doi:10.1001/archopht.1982.01030040278015

Amodiaquine Ocular Changes

Lawrence W. Hirst, George Sanborn, W. Richard Green, Neil R. Miller, William D. Heath

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A 34-year-old man ingested more than 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous inclusions in corneal epithelial cells, conjunctival epithelial cells, keratocytes, and vascular endothelial cells. Follow-up of more than two years and repeated conjunctival biopsy specimens revealed diminution in both the clinical and electron microscopic abnormalities, but persistence in abnormal results of retinal function tests. These changes are consistent with a druginduced phospholipidosis.

Original language	English (US)
Pages (from-to)	1300-1304
Number of pages	5
Journal	Archives of ophthalmology
Volume	100
Issue number	8
DOIs	https://doi.org/10.1001/archopht.1982.01030040278015
State	Published - Aug 1982

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1001/archopht.1982.01030040278015

Cite this

@article{61fdde4b6d244f8b9baebd2c2203480f,

title = "Amodiaquine Ocular Changes",

abstract = "A 34-year-old man ingested more than 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous inclusions in corneal epithelial cells, conjunctival epithelial cells, keratocytes, and vascular endothelial cells. Follow-up of more than two years and repeated conjunctival biopsy specimens revealed diminution in both the clinical and electron microscopic abnormalities, but persistence in abnormal results of retinal function tests. These changes are consistent with a druginduced phospholipidosis.",

author = "Hirst, {Lawrence W.} and George Sanborn and Green, {W. Richard} and Miller, {Neil R.} and Heath, {William D.}",

year = "1982",

month = aug,

doi = "10.1001/archopht.1982.01030040278015",

language = "English (US)",

volume = "100",

pages = "1300--1304",

journal = "Archives of ophthalmology",

issn = "0003-9950",

publisher = "American Medical Association",

number = "8",

}

TY - JOUR

T1 - Amodiaquine Ocular Changes

AU - Hirst, Lawrence W.

AU - Sanborn, George

AU - Green, W. Richard

AU - Miller, Neil R.

AU - Heath, William D.

PY - 1982/8

Y1 - 1982/8

N2 - A 34-year-old man ingested more than 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous inclusions in corneal epithelial cells, conjunctival epithelial cells, keratocytes, and vascular endothelial cells. Follow-up of more than two years and repeated conjunctival biopsy specimens revealed diminution in both the clinical and electron microscopic abnormalities, but persistence in abnormal results of retinal function tests. These changes are consistent with a druginduced phospholipidosis.

AB - A 34-year-old man ingested more than 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous inclusions in corneal epithelial cells, conjunctival epithelial cells, keratocytes, and vascular endothelial cells. Follow-up of more than two years and repeated conjunctival biopsy specimens revealed diminution in both the clinical and electron microscopic abnormalities, but persistence in abnormal results of retinal function tests. These changes are consistent with a druginduced phospholipidosis.

UR - http://www.scopus.com/inward/record.url?scp=0019951214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019951214&partnerID=8YFLogxK

U2 - 10.1001/archopht.1982.01030040278015

DO - 10.1001/archopht.1982.01030040278015

M3 - Article

C2 - 7103815

AN - SCOPUS:0019951214

SN - 0003-9950

VL - 100

SP - 1300

EP - 1304

JO - Archives of ophthalmology

JF - Archives of ophthalmology

IS - 8

ER -

Amodiaquine Ocular Changes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this