Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A

Vasudha Sharma; Gilbert T. Kelly; Jennifer Foulke-Abel; Coran M.H. Watanabe

doi:10.1021/ol9016639

Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A

Vasudha Sharma, Gilbert T. Kelly, Jennifer Foulke-Abel, Coran M.H. Watanabe

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

Original language	English (US)
Pages (from-to)	4006-4009
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	17
DOIs	https://doi.org/10.1021/ol9016639
State	Published - Sep 3 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol9016639

Cite this

@article{ab26ce8f06e8498c9dd07a884e000801,

title = "Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A",

abstract = "Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.",

author = "Vasudha Sharma and Kelly, {Gilbert T.} and Jennifer Foulke-Abel and Watanabe, {Coran M.H.}",

year = "2009",

month = sep,

day = "3",

doi = "10.1021/ol9016639",

language = "English (US)",

volume = "11",

pages = "4006--4009",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A

AU - Sharma, Vasudha

AU - Kelly, Gilbert T.

AU - Foulke-Abel, Jennifer

AU - Watanabe, Coran M.H.

PY - 2009/9/3

Y1 - 2009/9/3

N2 - Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

AB - Experiments reveal that the metabolic precursor aminoacetone is a key intermediate in the production of the antitumor agent azinomycin A relative to the structurally and functionally related agent, azinomycin B. Azinomycin A and B arise through bifurcation of the biosynthetic pathway and competition between metabolic substrates. The availability of the biosynthetic precursors in vivo, aminoacetone for azinomycin A and threonine for azinomycin B, controls the overall ratio of azinomycin A to B produced.

UR - http://www.scopus.com/inward/record.url?scp=69449096273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69449096273&partnerID=8YFLogxK

U2 - 10.1021/ol9016639

DO - 10.1021/ol9016639

M3 - Article

C2 - 19663419

AN - SCOPUS:69449096273

SN - 1523-7060

VL - 11

SP - 4006

EP - 4009

JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Aminoacetone as the penultimate precursor to the antitumor agent azinomycin A

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this