Amide proton transfer MR imaging of prostate cancer: A preliminary study

Guang Jia, Ronney Abaza, Jo Anna D. Williams, Debra L. Zynger, Jinyuan Zhou, Zarine K. Shah, Mitva Patel, Steffen Sammet, Lai Wei, Robert R. Bahnson, Michael V. Knopp

Research output: Contribution to journalArticlepeer-review

128 Scopus citations


Purpose: To evaluate the capability of amide proton transfer (APT) MR imaging for detection of prostate cancer that typically shows a higher tumor cell proliferation rate and cellular density leading to an MRI-detectable overall elevated mobile protein level in higher grade tumors. Materials and Methods: Twelve patients with biopsy-proven prostate cancer were imaged on a 3 Tesla MR imaging system before prostatectomy. APT-MR images were acquired by means of a single-slice single-shot turbo spin echo sequence with a saturation prepulse preparation using 33 different frequency offsets (-8 to 8 ppm, interval 0.5 ppm). For quantification we used the APT ratio (APTR) based on the asymmetry of the magnetization transfer ratio at 3.5 ppm in respect to the water signal. Tumor and peripheral zone benign regions of interest (ROIs) were delineated based on whole mount pathology slides after prostatectomy. Results: APTR in prostate cancer ROIs was 5.8% ± 3.2%, significantly higher than that in the peripheral zone benign regions (0.3% ± 3.2%, P = 0.002). Conclusion: APT-MR imaging is feasible in prostate cancer detection and has the potential to discriminate between cancer and noncancer tissues.

Original languageEnglish (US)
Pages (from-to)647-654
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number3
StatePublished - Mar 2011


  • Amide proton transfer
  • Chemical exchange saturation transfer
  • Mobile protein level
  • Molecular imaging
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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