Amide proton transfer imaging of human brain tumors at 3T

Craig K. Jones, Michael J. Schlosser, Peter C.M. Van Zijl, Martin G. Pomper, Xavier Golay, Jinyuan Zhou

Research output: Contribution to journalArticlepeer-review

238 Scopus citations


Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water-exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole-body clinical scanner and compared with T1- (T1w) and T2-weighted (T2w), fluid-attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT-weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal-appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures.

Original languageEnglish (US)
Pages (from-to)585-592
Number of pages8
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Sep 2006


  • APT
  • Amide proton exchange
  • Brain tumor
  • CEST
  • MT
  • Magnetization transfer
  • Protein

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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