Amide proton transfer imaging of Alzheimer's disease and Parkinson's disease: Dedicated to Professor Chaohui Ye on the occasion of his 80th birthday

Chunmei Li, Jinyuan Zhou, Di Wang, Xinyang Li, Shanshan Jiang, Yi Zhang, Zhibo Wen, Guangbin Wang, Fuhua Yan, Min Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecular imaging technique at the protein level in tissue. Neurodegenerative diseases have a high likelihood of causing abnormal protein accumulation in the brain, which can be detected by APT MRI. This article briefly introduces the principles and image processing technology of APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these two neurodegenerative diseases are encouraging, which also suggests continued technical development and larger clinical trials to gauge the value of this technique.

Original languageEnglish (US)
Pages (from-to)22-30
Number of pages9
JournalMagnetic Resonance Letters
Volume3
Issue number1
DOIs
StatePublished - Feb 2023

Keywords

  • Alzheimer's disease
  • Amide proton transfer imaging
  • MRI
  • Parkinson's disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Amide proton transfer imaging of Alzheimer's disease and Parkinson's disease: Dedicated to Professor Chaohui Ye on the occasion of his 80th birthday'. Together they form a unique fingerprint.

Cite this