TY - JOUR
T1 - American society of clinical oncology 2008 clinical practice guideline update
T2 - Use of chemotherapy and radiation therapy protectants
AU - Hensley, Martee L.
AU - Hagerty, Karen L.
AU - Kewalramani, Tarun
AU - Green, Daniel M.
AU - Meropol, Neal J.
AU - Wasserman, Todd H.
AU - Cohen, Gary I.
AU - Emami, Bahman
AU - Gradishar, William J.
AU - Brian Mitchell, R.
AU - Thigpen, J. Tate
AU - Trotti, Andy
AU - Von Hoff, Daniel
AU - Schuchter, Lynn M.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Purpose: To update a clinical practice guideline on the use of chemotherapy and radiation therapy protectants for patients with cancer. Methods:An update committee reviewed literature published since the last guideline update in 2002.Results: Thirty-nine reports met the inclusion criteria: palifermin and dexrazoxane, three reports (two studies) each; amifostine, 33 reports (31 studies); and mesna, no published randomized trials identified since 2002. Recommendations: Dexrazoxane is not recommended for routine use in breast cancer (BC) in adjuvant setting, or metastatic setting with initial doxorubicin-based chemotherapy. Consider use with metastatic BC and other malignancies, for patients who have received more than 300 mg/m2 doxorubicin who may benefit from continued doxorubicin-containing therapy. Cardiac monitoring should continue in patients receiving doxorubicin. Amifostine may be considered for prevention of cisplatin-associated nephrotoxicity, reduction of grade 3 to 4 neutropenia (alternative strategies are reasonable), and to decrease acute and late xerostomia with fractionated radiation therapy alone for head and neck cancer. It is not recommended for protection against thrombocytopenia, prevention of platinum-associated neurotoxicity or ototoxicity or paclitaxel-associated neuropathy, prevention of radiation therapy-associated mucositis in head and neck cancer, or prevention of esophagitis during concurrent chemoradiotherapy for non-small-cell lung cancer. Palifermin is recommended to decrease severe mucositis in autologous stem-cell transplantation (SCT) for hematologic malignancies with total-body irradiation (TBI) conditioning regimens, and considered for patients undergoing myeloablative allogeneic SCT with TBI-based conditioning regimens. Data are insufficient to recommend use in the non-SCT setting.
AB - Purpose: To update a clinical practice guideline on the use of chemotherapy and radiation therapy protectants for patients with cancer. Methods:An update committee reviewed literature published since the last guideline update in 2002.Results: Thirty-nine reports met the inclusion criteria: palifermin and dexrazoxane, three reports (two studies) each; amifostine, 33 reports (31 studies); and mesna, no published randomized trials identified since 2002. Recommendations: Dexrazoxane is not recommended for routine use in breast cancer (BC) in adjuvant setting, or metastatic setting with initial doxorubicin-based chemotherapy. Consider use with metastatic BC and other malignancies, for patients who have received more than 300 mg/m2 doxorubicin who may benefit from continued doxorubicin-containing therapy. Cardiac monitoring should continue in patients receiving doxorubicin. Amifostine may be considered for prevention of cisplatin-associated nephrotoxicity, reduction of grade 3 to 4 neutropenia (alternative strategies are reasonable), and to decrease acute and late xerostomia with fractionated radiation therapy alone for head and neck cancer. It is not recommended for protection against thrombocytopenia, prevention of platinum-associated neurotoxicity or ototoxicity or paclitaxel-associated neuropathy, prevention of radiation therapy-associated mucositis in head and neck cancer, or prevention of esophagitis during concurrent chemoradiotherapy for non-small-cell lung cancer. Palifermin is recommended to decrease severe mucositis in autologous stem-cell transplantation (SCT) for hematologic malignancies with total-body irradiation (TBI) conditioning regimens, and considered for patients undergoing myeloablative allogeneic SCT with TBI-based conditioning regimens. Data are insufficient to recommend use in the non-SCT setting.
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U2 - 10.1200/JCO.2008.17.2627
DO - 10.1200/JCO.2008.17.2627
M3 - Article
C2 - 19018081
AN - SCOPUS:58149335531
SN - 0732-183X
VL - 27
SP - 127
EP - 145
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 1
ER -