TY - JOUR
T1 - American Radium Society (ARS) Appropriate Use Criteria (AUC) for Extrahepatic Cholangiocarcinoma
AU - Tchelebi, Leila T.
AU - Jethwa, Krishan R.
AU - Levy, Anna T.
AU - Anker, Christopher J.
AU - Kennedy, Timothy
AU - Grodstein, Elliot
AU - Hallemeier, Christopher L.
AU - Jabbour, Salma K.
AU - Kim, Ed
AU - Kumar, Rachit
AU - Lee, Percy
AU - Small, William
AU - Williams, Vonetta M.
AU - Sharma, Navesh
AU - Russo, Suzanne
N1 - Publisher Copyright:
Copyright © 2022 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.Unauthorized reproduction of this article is prohibited.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Although uncommon, extrahepatic cholangiocarcinoma (EHCC) is a deadly malignancy, and the treatment approaches remain controversial. While surgery remains the only cure, few patients are candidates for resection up front, and there are high rates of both local and distant failure following resection. Herein, we systematically review the available evidence regarding treatment approaches for patients with EHCC, including surgery, radiation, and chemotherapy. The evidence regarding treatment outcomes was assessed using the Population, Intervention, Comparator, Outcome, and Study design (PICOS) framework. A summary of recommendations based on the available literature is outlined for specific clinical scenarios encountered by providers in the clinic to guide the management of these patients.
AB - Although uncommon, extrahepatic cholangiocarcinoma (EHCC) is a deadly malignancy, and the treatment approaches remain controversial. While surgery remains the only cure, few patients are candidates for resection up front, and there are high rates of both local and distant failure following resection. Herein, we systematically review the available evidence regarding treatment approaches for patients with EHCC, including surgery, radiation, and chemotherapy. The evidence regarding treatment outcomes was assessed using the Population, Intervention, Comparator, Outcome, and Study design (PICOS) framework. A summary of recommendations based on the available literature is outlined for specific clinical scenarios encountered by providers in the clinic to guide the management of these patients.
KW - Extrahepatic cholangiocarcinoma
KW - chemotherapy
KW - liver transplant
KW - radiation therapy
KW - surgery
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U2 - 10.1097/COC.0000000000000969
DO - 10.1097/COC.0000000000000969
M3 - Article
C2 - 36534388
AN - SCOPUS:85146949797
SN - 0277-3732
VL - 46
SP - 73
EP - 84
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 2
ER -