Amelioration of negative symptoms in schizophrenia by glycine

Daniel C. Javitt, Ilana Zylberman, Stephen R. Zukin, Uriel Heresco-Levy, Jean Pierre Lindenmayer

Research output: Contribution to journalArticlepeer-review

308 Scopus citations


Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double- blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor- mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.

Original languageEnglish (US)
Pages (from-to)1234-1236
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number8
StatePublished - Aug 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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