Abstract
Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double- blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor- mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.
Original language | English (US) |
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Pages (from-to) | 1234-1236 |
Number of pages | 3 |
Journal | American Journal of Psychiatry |
Volume | 151 |
Issue number | 8 |
State | Published - Aug 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Psychiatry and Mental health