Amelioration of negative symptoms in schizophrenia by glycine

Daniel C. Javitt; Ilana Zylberman; Stephen R. Zukin; Uriel Heresco-Levy; Jean Pierre Lindenmayer

Amelioration of negative symptoms in schizophrenia by glycine

Daniel C. Javitt, Ilana Zylberman, Stephen R. Zukin, Uriel Heresco-Levy, Jean Pierre Lindenmayer

Research output: Contribution to journal › Article › peer-review

Abstract

Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double- blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor- mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.

Original language	English (US)
Pages (from-to)	1234-1236
Number of pages	3
Journal	American Journal of Psychiatry
Volume	151
Issue number	8
State	Published - Aug 1994
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health

Cite this

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title = "Amelioration of negative symptoms in schizophrenia by glycine",

abstract = "Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double- blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor- mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.",

author = "Javitt, {Daniel C.} and Ilana Zylberman and Zukin, {Stephen R.} and Uriel Heresco-Levy and Lindenmayer, {Jean Pierre}",

year = "1994",

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language = "English (US)",

volume = "151",

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journal = "American Journal of Psychiatry",

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T1 - Amelioration of negative symptoms in schizophrenia by glycine

AU - Javitt, Daniel C.

AU - Zylberman, Ilana

AU - Zukin, Stephen R.

AU - Heresco-Levy, Uriel

AU - Lindenmayer, Jean Pierre

PY - 1994/8

Y1 - 1994/8

N2 - Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double- blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor- mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.

AB - Phencyclidine induces a psychotomimetic state by blocking neurotransmission at N-methyl-D-aspartic acid (NMDA) receptors. In a double- blind, placebo-controlled fashion, 14 medicated patients with chronic schizophrenia were treated with glycine, a potentiator of NMDA-receptor- mediated neurotransmission. Significant improvement in negative symptoms occurred in the group given glycine but not in the group given placebo, suggesting that potentiation of NMDA-receptor-mediated neurotransmission may represent an effective treatment for neuroleptic-resistant negative symptoms in schizophrenia.

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M3 - Article

C2 - 8037263

AN - SCOPUS:0028015607

SN - 0002-953X

VL - 151

SP - 1234

EP - 1236

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

IS - 8

ER -

Amelioration of negative symptoms in schizophrenia by glycine

Abstract

ASJC Scopus subject areas

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