Alzheimer's disease and related dementias: Selective involvement of specific neuronal systems

P. J. Whitehouse, R. G. Struble, J. C. Hedreen, A. W. Clark, D. L. Price

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


The degenerative disorders of the CNS are of considerable historical, social, economical, and neurobiological significance. This review has provided a framework for investigations of the disordered brain-behavior relationships occurring in these particular conditions. For heuristic purposes, our discussion had focused on the cholinergic and noradrenergic cortical projecting systems in AD and related dementias. However, changes in neurons of these systems are only one feature of the pathology of AD and related dementias and, as such, this review represents a simplification of a more complicated pathophysiology. While we have focused on selective examples, we feel that the approach defined in this review is applicable to a variety of neuronal populations in a variety of degenerative diseases of the CNS.

Original languageEnglish (US)
Pages (from-to)319-339
Number of pages21
JournalCRC Critical Reviews in Clinical Neurobiology
Issue number4
StatePublished - 1985

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology


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