Alzheimer peptides perturb lipid-regulating enzymes

Mark P. Mattson, Roy G. Cutler, Dong Gyu Jo

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


An increase in the size of the amyloid β-peptide (Aβ versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

Original languageEnglish (US)
Pages (from-to)1045-1047
Number of pages3
JournalNature Cell Biology
Issue number11
StatePublished - Nov 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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