Alzheimer diseases

Alena V. Savonenko, Philip C. Wong, Tong Li

Research output: Chapter in Book/Report/Conference proceedingChapter


Over the past several years, significant advances have been made in many areas of Alzheimer's disease (AD) research. Here, we review several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.

Original languageEnglish (US)
Title of host publicationNeurobiology of Brain Disorders
Subtitle of host publicationBiological Basis of Neurological and Psychiatric Disorders, Second Edition
Number of pages24
ISBN (Electronic)9780323856546
ISBN (Print)9780323898256
StatePublished - Jan 1 2022


  • Amyloid precursor protein (APP)
  • Aβ plaques
  • Neurofibrillary tangles (NFT)
  • Tau
  • β-site APP cleaving enzyme-1 (BACE 1)
  • γ-Secretase

ASJC Scopus subject areas

  • General Neuroscience


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