Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

Peter J. Whitehouse; Donald L. Price; Arthur W. Clark; Joseph T. Coyle; Mahlon R. DeLong

doi:10.1002/ana.410100203

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

Peter J. Whitehouse, Donald L. Price, Arthur W. Clark, Joseph T. Coyle, Mahlon R. DeLong

School of Medicine

Research output: Contribution to journal › Article › peer-review

1387 Scopus citations

Abstract

The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.

Original language	English (US)
Pages (from-to)	122-126
Number of pages	5
Journal	Annals of neurology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1002/ana.410100203
State	Published - Aug 1981

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.410100203

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title = "Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis",

abstract = "The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.",

author = "Whitehouse, {Peter J.} and Price, {Donald L.} and Clark, {Arthur W.} and Coyle, {Joseph T.} and DeLong, {Mahlon R.}",

year = "1981",

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AU - Price, Donald L.

AU - Clark, Arthur W.

AU - Coyle, Joseph T.

AU - DeLong, Mahlon R.

PY - 1981/8

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N2 - The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.

AB - The nucleus basalis of Meynert provides diffuse cholinergic input to the neocortex. When compared with an age‐ and sex‐matched control, the nucleus basalis from a patient with Alzheimer disease demonstrated substantial reduction of neurons. Loss of this neuronal population may represent an anatomical correlate of the well‐documented cholinergic derangement in Alzheimer disease.

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Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

Abstract

ASJC Scopus subject areas

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