Alzheimer dementia: Quantification of energy metabolism and mobile phosphoesters with P-31 NMR spectroscopy

Paul A. Bottomley, Joseph P. Cousins, Deanna L. Pendrey, William A. Wagle, Christopher J. Hardy, Fred A. Eames, Robert J. McCaffrey, Dean A. Thompson

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

To determine whether high-energy phosphate metabolism and mobile phosphoester indexes of membrane metabolism are altered in Alzheimer disease and to help resolve some inconsistencies in the literature, brain phosphate metabolite concentrations and ratios were measured in 11 patients with mild to severe dementia of the probable Alzheimer type and 14 healthy subjects. Fully relaxed, spatially localized, phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy and proton (hydro-gen-1) MR imaging were performed. No significant differences were found in the concentrations and relative ratios of phosphocreatine, nucleoside triphosphate, inorganic phosphate, phosphomonoester, and phosphodiesters in whole axial sections through the lateral cerebral ventricles of the brain that could not be accounted for by atrophy. There was no correlation between P-31 NMR indexes and the severity of dementia as assessed with neuropsychologic testing. High-energy phosphate and membrane metabolism, as detected in vivo with P-31 NMR spectroscopy in whole-brain sections, do not appear to play a major role in the disease process, except as a direct consequence of atrophy quantified with H-1 MR imaging.

Original languageEnglish (US)
Pages (from-to)695-699
Number of pages5
JournalRADIOLOGY
Volume183
Issue number3
DOIs
StatePublished - Jun 1992
Externally publishedYes

Keywords

  • Brain, MR, 10.1214
  • Brain, atrophy, 10.83
  • Brain, diseases, 10.83
  • Ementia, 10.83
  • Magnetic resonance (MR), phosphorus studies, 10.1214
  • Magnetic resonance (MR), spectroscopy, 10.1214

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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