Alternative Clinical Trial Design in Neurocritical Care

Christos Lazaridis, Andrew I.R. Maas, Michael J. Souter, Renee H. Martin, Randal M. Chesnut, Stacia M. DeSantis, Gene Sung, Peter D. Leroux, Jose I. Suarez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Neurocritical care involves the care of highly complex patients with combinations of physiologic derangements in the brain and in extracranial organs. The level of evidence underpinning treatment recommendations remains low due to a multitude of reasons including an incomplete understanding of the involved physiology; lack of good quality, prospective, standardized data; and the limited success of conventional randomized controlled trials. Comparative effectiveness research can provide alternative perspectives and methods to enhance knowledge and evidence within the field of neurocritical care; these include large international collaborations for generation and maintenance of high quality data, statistical methods that incorporate heterogeneity and individualize outcome prediction, and finally advanced bioinformatics that integrate large amounts of variable-source data into patient-specific phenotypes and trajectories.

Original languageEnglish (US)
Pages (from-to)378-384
Number of pages7
JournalNeurocritical care
Issue number3
StatePublished - Jun 1 2015
Externally publishedYes


  • Comparative effectiveness research
  • Neurocritical care
  • Neuromonitoring
  • Randomized controlled trials
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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