Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

L. A. Birder, Y. Nakamura, S. Kiss, M. L. Nealen, S. Barrick, A. J. Kanai, E. Wang, G. Ruiz, W. C. De Groat, G. Apodaca, S. Watkins, M. J. Caterina

Research output: Contribution to journalArticlepeer-review

556 Scopus citations

Abstract

In the urinary bladder, the capsaicin-gated ion channel TRPV1 is expressed both within afferent nerve terminals and within the epithelial cells that line the bladder lumen. To determine the significance of this expression pattern, we analyzed bladder function in mice lacking TRPV1. Compared with wild-type littermates, trpv1−/− mice had a higher frequency of low-amplitude, non-voiding bladder contractions. This alteration was accompanied by reductions in both spinal cord signaling and reflex voiding during bladder filling (under anesthesia). In vitro, stretch-evoked ATP release and membrane capacitance changes were diminished in bladders excised from trpv1−/− mice, as was hypoosmolality-evoked ATP release from cultured trpv1−/− urothelial cells. These findings indicate that TRPV1 participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.

Original languageEnglish (US)
Pages (from-to)856-860
Number of pages5
JournalNature neuroscience
Volume5
Issue number9
DOIs
StatePublished - Sep 2002

ASJC Scopus subject areas

  • General Neuroscience

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