TY - JOUR
T1 - Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii
AU - Frank, Oliver
AU - Jones-Brando, Lorraine
AU - Leib-Mösch, Christine
AU - Yolken, Robert
AU - Seifarth, Wolfgang
N1 - Funding Information:
Received 31 May 2006; accepted 17 July 2006; electronically published 10 October 2006. Presented in part: Stanley Medical Research Institute Symposium entitled “Toxoplasma Infections in the Immune Competent Host—Possible Applications to Human Neuropsychiatric Disorders,” 11 November 2005, Annapolis, Maryland (oral presentation, no abstract available). Potential conflicts of interest: none reported. Financial support: Stanley Medical Research Institute, Theodore and Vada Stanley Foundation (grant 05R-893 to O.F.). a These authors contributed equally to this work. Reprints or correspondence: Dr. Wolfgang Seifarth, Medizinische Universitätsklinik III, Medizinische Fakultät Mannheim der Universität Heidelberg, Wiesbadener Straße 7-11, D-68305 Mannheim, Germany (wolfgang.seifarth@urz.uni-heidelberg.de).
PY - 2006/11/15
Y1 - 2006/11/15
N2 - Human endogenous retroviruses (HERVs) arose in antiquity from stable integration into the human genome. The mechanism for activation of HERVs has not been fully elucidated. Toxoplasmosis, caused by Toxoplasma gondii, is a medically important parasitic infection with worldwide distribution. To search for a tentative link between toxoplasmosis and HERV activation, HERV expression profiles of human neuroepithelial SK-N-MC cells infected with T. gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells.
AB - Human endogenous retroviruses (HERVs) arose in antiquity from stable integration into the human genome. The mechanism for activation of HERVs has not been fully elucidated. Toxoplasmosis, caused by Toxoplasma gondii, is a medically important parasitic infection with worldwide distribution. To search for a tentative link between toxoplasmosis and HERV activation, HERV expression profiles of human neuroepithelial SK-N-MC cells infected with T. gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells.
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U2 - 10.1086/508496
DO - 10.1086/508496
M3 - Article
C2 - 17054075
AN - SCOPUS:33750743153
SN - 0022-1899
VL - 194
SP - 1447
EP - 1449
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -