Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart

Hongwei Jin; Robert D. Nass; Paul J. Joudrey; Alexander R. Lyon; Elie R. Chemaly; Kleopatra Rapti; Fadi G. Akar

doi:10.1016/j.bpj.2010.01.045

Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart

Hongwei Jin, Robert D. Nass, Paul J. Joudrey, Alexander R. Lyon, Elie R. Chemaly, Kleopatra Rapti, Fadi G. Akar

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (Δψ_m) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of Δψ_m within the intact heart during ischemla-reperfuslon injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate Δψ_m spatiotemporal properties and arrhythmia propensity.

Original language	English (US)
Pages (from-to)	2063-2071
Number of pages	9
Journal	Biophysical journal
Volume	98
Issue number	10
DOIs	https://doi.org/10.1016/j.bpj.2010.01.045
State	Published - May 19 2010
Externally published	Yes

ASJC Scopus subject areas

Biophysics

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10.1016/j.bpj.2010.01.045

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title = "Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart",

abstract = "Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (Δψm) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of Δψm within the intact heart during ischemla-reperfuslon injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate Δψm spatiotemporal properties and arrhythmia propensity.",

author = "Hongwei Jin and Nass, {Robert D.} and Joudrey, {Paul J.} and Lyon, {Alexander R.} and Chemaly, {Elie R.} and Kleopatra Rapti and Akar, {Fadi G.}",

note = "Funding Information: This study was supported by grants to F.G.A. from the American Heart Association (0830126N); the National Heart, Lung and Blood Institute, National Institutes of Health (HL091923); the Irma T. Hirschl and Monique Weill Caullier Trusts; and the Celladon Corporation.",

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AU - Jin, Hongwei

AU - Nass, Robert D.

AU - Joudrey, Paul J.

AU - Lyon, Alexander R.

AU - Chemaly, Elie R.

AU - Rapti, Kleopatra

AU - Akar, Fadi G.

N1 - Funding Information: This study was supported by grants to F.G.A. from the American Heart Association (0830126N); the National Heart, Lung and Blood Institute, National Institutes of Health (HL091923); the Irma T. Hirschl and Monique Weill Caullier Trusts; and the Celladon Corporation.

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N2 - Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (Δψm) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of Δψm within the intact heart during ischemla-reperfuslon injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate Δψm spatiotemporal properties and arrhythmia propensity.

AB - Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (Δψm) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of Δψm within the intact heart during ischemla-reperfuslon injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate Δψm spatiotemporal properties and arrhythmia propensity.

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Altered spatiotemporal dynamics of the mitochondrial membrane potential in the hypertrophied heart

Abstract

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