Altered free associations: Some cognitive effects of DOET (2, 5‐dimethoxy‐4‐ethylamphetamine)

Normal adult males were administered DOET (2, 5‐dimethoxy‐4‐ethylamphetamine) and d‐amphetamine, at two separate times in a double blind experimental design. DOET in low doses (1.5 mg/70 kg) produced no gross behavioral or perceptual design. DOET did alter Ss' free associations at the time of maximal drug uptake. Ss produced lower frequency, less common, free associations with DOET. Although the associations Ss produced with DOET occur less frequently in association norms they were neither bizarre or idiosyncratic responses. In addition, these free associations were at least as reproducible as the associations produced under no drug or amphetamine conditions. This new psychotropic agent, in low doses, appears to be particularly effective in altering normal cognition without producing disorganization in thinking or perception.