Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration

P. R. Rapp, R. F. Fanelli, M. McGuire, R. A. Rosenberg, M. Gallagher

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [3H]desmethylimipramine ([3H]DMI) binding in the aged rat brain. Small circular patches of intense [3H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [3H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [3H]DMI binding are anatomically restricted to the loci indicated above.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalNeuroscience Letters
Issue number1-2
StatePublished - Aug 18 1987
Externally publishedYes


  • Aging
  • In vitro autoradiography
  • Rat
  • [H]Desmethylimipramine binding

ASJC Scopus subject areas

  • General Neuroscience


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