Alterations in exocrine pancreatic function after acute pancreatitis

Joseph Bejjani; Mitchell L. Ramsey; Peter J. Lee; Anna Evans Phillips; Vikesh K. Singh; Dhiraj Yadav; Georgios I. Papachristou; Phil A. Hart

doi:10.1016/j.pan.2024.03.003

Alterations in exocrine pancreatic function after acute pancreatitis

Joseph Bejjani, Mitchell L. Ramsey, Peter J. Lee, Anna Evans Phillips, Vikesh K. Singh, Dhiraj Yadav, Georgios I. Papachristou, Phil A. Hart

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Exocrine pancreatic dysfunction (EPD) is a malabsorptive complication of pancreatic disorders that can lead to a host of symptoms ranging from flatulence to diarrhea and contribute to weight loss and metabolic bone disease. It is increasingly recognized to occur after acute pancreatitis (AP), including episodes with mild severity. The risk of developing EPD after AP is influenced by a range of factors, including the degree of acinar cell destruction and inflammation during AP, and persistent structural derangements following AP. In this article, we discuss the epidemiology, pathophysiology, and clinical management of EPD after AP while highlighting key knowledge gaps.

Original language	English (US)
Journal	Pancreatology
DOIs	https://doi.org/10.1016/j.pan.2024.03.003
State	Accepted/In press - 2024

Keywords

Exocrine pancreatic dysfunction
Exocrine pancreatic insufficiency
Pancreatic enzymes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Hepatology
Endocrinology

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10.1016/j.pan.2024.03.003

Cite this

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title = "Alterations in exocrine pancreatic function after acute pancreatitis",

abstract = "Exocrine pancreatic dysfunction (EPD) is a malabsorptive complication of pancreatic disorders that can lead to a host of symptoms ranging from flatulence to diarrhea and contribute to weight loss and metabolic bone disease. It is increasingly recognized to occur after acute pancreatitis (AP), including episodes with mild severity. The risk of developing EPD after AP is influenced by a range of factors, including the degree of acinar cell destruction and inflammation during AP, and persistent structural derangements following AP. In this article, we discuss the epidemiology, pathophysiology, and clinical management of EPD after AP while highlighting key knowledge gaps.",

keywords = "Exocrine pancreatic dysfunction, Exocrine pancreatic insufficiency, Pancreatic enzymes",

author = "Joseph Bejjani and Ramsey, {Mitchell L.} and Lee, {Peter J.} and Phillips, {Anna Evans} and Singh, {Vikesh K.} and Dhiraj Yadav and Papachristou, {Georgios I.} and Hart, {Phil A.}",

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year = "2024",

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language = "English (US)",

journal = "Pancreatology",

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T1 - Alterations in exocrine pancreatic function after acute pancreatitis

AU - Bejjani, Joseph

AU - Ramsey, Mitchell L.

AU - Lee, Peter J.

AU - Phillips, Anna Evans

AU - Singh, Vikesh K.

AU - Yadav, Dhiraj

AU - Papachristou, Georgios I.

AU - Hart, Phil A.

PY - 2024

Y1 - 2024

N2 - Exocrine pancreatic dysfunction (EPD) is a malabsorptive complication of pancreatic disorders that can lead to a host of symptoms ranging from flatulence to diarrhea and contribute to weight loss and metabolic bone disease. It is increasingly recognized to occur after acute pancreatitis (AP), including episodes with mild severity. The risk of developing EPD after AP is influenced by a range of factors, including the degree of acinar cell destruction and inflammation during AP, and persistent structural derangements following AP. In this article, we discuss the epidemiology, pathophysiology, and clinical management of EPD after AP while highlighting key knowledge gaps.

AB - Exocrine pancreatic dysfunction (EPD) is a malabsorptive complication of pancreatic disorders that can lead to a host of symptoms ranging from flatulence to diarrhea and contribute to weight loss and metabolic bone disease. It is increasingly recognized to occur after acute pancreatitis (AP), including episodes with mild severity. The risk of developing EPD after AP is influenced by a range of factors, including the degree of acinar cell destruction and inflammation during AP, and persistent structural derangements following AP. In this article, we discuss the epidemiology, pathophysiology, and clinical management of EPD after AP while highlighting key knowledge gaps.

KW - Exocrine pancreatic dysfunction

KW - Exocrine pancreatic insufficiency

KW - Pancreatic enzymes

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UR - http://www.scopus.com/inward/citedby.url?scp=85187657528&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2024.03.003

DO - 10.1016/j.pan.2024.03.003

M3 - Review article

C2 - 38485543

AN - SCOPUS:85187657528

SN - 1424-3903

JO - Pancreatology

JF - Pancreatology

ER -

Alterations in exocrine pancreatic function after acute pancreatitis

Abstract

Keywords

ASJC Scopus subject areas

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