Alterations in exocrine pancreatic function after acute pancreatitis

Joseph Bejjani, Mitchell L. Ramsey, Peter J. Lee, Anna Evans Phillips, Vikesh K. Singh, Dhiraj Yadav, Georgios I. Papachristou, Phil A. Hart

Research output: Contribution to journalReview articlepeer-review


Exocrine pancreatic dysfunction (EPD) is a malabsorptive complication of pancreatic disorders that can lead to a host of symptoms ranging from flatulence to diarrhea and contribute to weight loss and metabolic bone disease. It is increasingly recognized to occur after acute pancreatitis (AP), including episodes with mild severity. The risk of developing EPD after AP is influenced by a range of factors, including the degree of acinar cell destruction and inflammation during AP, and persistent structural derangements following AP. In this article, we discuss the epidemiology, pathophysiology, and clinical management of EPD after AP while highlighting key knowledge gaps.

Original languageEnglish (US)
StateAccepted/In press - 2024


  • Exocrine pancreatic dysfunction
  • Exocrine pancreatic insufficiency
  • Pancreatic enzymes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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