Alpha2-adrenoceptor and NO mediate the opioid subsensitivity in isolated tissues of cholestatic animals

S. Demehri, M. Samini, K. Namiranian, H. Rastegar, S. E. Mehr, H. Homayoun, F. Roushanzamir, M. Jorjani, A. R. Dehpour

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


1 Our previous report showed that in acute cholestasis, the subsensitivity to morphine inhibitory effect on electrical-stimulated contractions develops significantly faster in guinea-pig ileum (GPI) and in mouse vas deferens (MVD) (45.2 and 29.9 times, respectively) compared with non-cholestatic subjects. 2 The possible contribution of α2-adrenoceptor and nitric oxide (NO) pathways on the development of tolerance was assessed in GPI and MVD of cholestatic subjects. 3 Daily administration of naltrexone (20 mg kg -1), yohimbine (5 mg kg-1), and Nω -nitro-L-arginine methyl ester (L-NAME) (3 mg kg-1) to cholestatic animals significantly (P-value < 0.05) inhibited the process of subsensitivity in all groups. 4 Consistent with the literature, it was concluded that both the α2-adrenergic system and NO have close interaction with the opioid system and may underlie some of the mechanisms involved in the subsensitivity development to opioids in acute cholestatic states.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalAutonomic and Autacoid Pharmacology
Issue number4
StatePublished - Aug 2003
Externally publishedYes


  • Cholestasis
  • Guinea-pig ileum
  • Mice vas deferens
  • Nitric oxide
  • α-adrenoceptors

ASJC Scopus subject areas

  • Pharmacology


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