Allergen immunotherapy: Therapeutic vaccines for allergic diseases - A WHO position paper

Jean Bousquet, Richard Lockey, Hans Jorgen Malling, Emilio Alvarez-Cuesta, Giorgio W. Canonica, Martin D. Chapman, Peter J. Creticos, Jean Michel Dayer, Stephen R. Durham, Pascal Demoly, Robert J. Goldstein, Takeru Ishikawa, Koji Ito, Dietrich Kraft, Paul Henri Lambert, Henig Løwenstein, Ulrich Müller, Philip S. Norman, Robert E. Reisman, Rudolph ValentaErkka Valovirta, Hans Yssel

Research output: Contribution to journalArticlepeer-review

943 Scopus citations


The World Health Organization and various allergy, asthma, and immunology societies throughout the world met on January 27 through 29, 1997, in Geneva, Switzerland to write guidelines for allergen immunotherapy. Over the ensuing year, the editors and panel members reached a consensus about the information to include in the WHO position paper "Allergen immunotherapy: Therapeutic vaccines for allergic diseases." The historical term allergen extract was changed to allergen vaccine to reflect the fact that allergen vaccines are used in medicine as immune modifiers. The document summarizes the scientific literature and rationale for the appropriate use of such therapy to treat allergic rhinoconjunctivitis, allergic asthma, and Hymenoptera hypersensitivity. It also includes recommendations to improve safety, discusses new techniques being developed that may result in better efficacy and less risk, and offers recommendations for areas of additional and necessary research.

Original languageEnglish (US)
Pages (from-to)558-562
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Issue number4 II
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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