Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia

Melvin Mcinnis; T. Swift-Scanlanl; A. T. Mahoney; J. Vincent; G. Verheyen; T. Hung Lan; L. Oruc; O. Riess; C. Van Broeckhoven; H. Chen; J. L. Kennedy; D. F. MacKinnon; R. L. Margolis; Sylvia G. Simpson; Francis Joseph McMahon; E. Gershon; J. Nürnberger; T. Reich; J. R. Depaulo; C. A. Ross

doi:10.1038/sj.mp.4000747

Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia

Melvin Mcinnis, T. Swift-Scanlanl, A. T. Mahoney, J. Vincent, G. Verheyen, T. Hung Lan, L. Oruc, O. Riess, C. Van Broeckhoven, H. Chen, J. L. Kennedy, D. F. MacKinnon, R. L. Margolis, Sylvia G. Simpson, Francis Joseph McMahon, E. Gershon, J. Nürnberger, T. Reich, J. R. Depaulo, C. A. Ross

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Molecular psychiatry
Volume	5
Issue number	4
DOIs	https://doi.org/10.1038/sj.mp.4000747
State	Published - 2000

Keywords

Ataxia
Bipolar disorder
Schizophrenia
Triplet repeats

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1038/sj.mp.4000747

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Mcinnis, M., Swift-Scanlanl, T., Mahoney, A. T., Vincent, J., Verheyen, G., Hung Lan, T., Oruc, L., Riess, O., Van Broeckhoven, C., Chen, H., Kennedy, J. L., MacKinnon, D. F., Margolis, R. L., Simpson, S. G., McMahon, F. J., Gershon, E., Nürnberger, J., Reich, T., Depaulo, J. R., & Ross, C. A. (2000). Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia. Molecular psychiatry, 5(4), 439-442. https://doi.org/10.1038/sj.mp.4000747

Mcinnis, M, Swift-Scanlanl, T, Mahoney, AT, Vincent, J, Verheyen, G, Hung Lan, T, Oruc, L, Riess, O, Van Broeckhoven, C, Chen, H, Kennedy, JL, MacKinnon, DF , Margolis, RL, Simpson, SG, McMahon, FJ, Gershon, E, Nürnberger, J, Reich, T, Depaulo, JR & Ross, CA 2000, 'Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia', Molecular psychiatry, vol. 5, no. 4, pp. 439-442. https://doi.org/10.1038/sj.mp.4000747

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title = "Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia",

abstract = "CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.",

keywords = "Ataxia, Bipolar disorder, Schizophrenia, Triplet repeats",

author = "Melvin Mcinnis and T. Swift-Scanlanl and Mahoney, {A. T.} and J. Vincent and G. Verheyen and {Hung Lan}, T. and L. Oruc and O. Riess and {Van Broeckhoven}, C. and H. Chen and Kennedy, {J. L.} and MacKinnon, {D. F.} and Margolis, {R. L.} and Simpson, {Sylvia G.} and McMahon, {Francis Joseph} and E. Gershon and J. N{\"u}rnberger and T. Reich and Depaulo, {J. R.} and Ross, {C. A.}",

note = "Funding Information: This work was supported in part by NARSAD, the Stanley Foundation and NIH grant No. MH 01088. Dr Riess acknowledges Ana Maria Menezes Vieira-Saecker for excellent technical assistance and Professor JT Epplen for support.",

year = "2000",

doi = "10.1038/sj.mp.4000747",

language = "English (US)",

volume = "5",

pages = "439--442",

journal = "Molecular psychiatry",

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TY - JOUR

T1 - Allelic distribution of CTG18.1 in Caucasian populations

T2 - Association studies in bipolar disorder, schizophrenia, and ataxia

AU - Mcinnis, Melvin

AU - Swift-Scanlanl, T.

AU - Mahoney, A. T.

AU - Vincent, J.

AU - Verheyen, G.

AU - Hung Lan, T.

AU - Oruc, L.

AU - Riess, O.

AU - Van Broeckhoven, C.

AU - Chen, H.

AU - Kennedy, J. L.

AU - MacKinnon, D. F.

AU - Margolis, R. L.

AU - Simpson, Sylvia G.

AU - McMahon, Francis Joseph

AU - Gershon, E.

AU - Nürnberger, J.

AU - Reich, T.

AU - Depaulo, J. R.

AU - Ross, C. A.

N1 - Funding Information: This work was supported in part by NARSAD, the Stanley Foundation and NIH grant No. MH 01088. Dr Riess acknowledges Ana Maria Menezes Vieira-Saecker for excellent technical assistance and Professor JT Epplen for support.

PY - 2000

Y1 - 2000

N2 - CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.

AB - CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.

KW - Ataxia

KW - Bipolar disorder

KW - Schizophrenia

KW - Triplet repeats

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Allelic distribution of CTG18.1 in Caucasian populations: Association studies in bipolar disorder, schizophrenia, and ataxia

Abstract

Keywords

ASJC Scopus subject areas

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