@article{3a4f920ab4fd4accad9ce5d8b37de923,
title = "All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics",
abstract = "Human chromosome 21 (Hsa21) contains more than 500 genes, making trisomy 21 one of the most complex genetic perturbations compatible with life. The ultimate goal of Down syndrome (DS) research is to design therapies that improve quality of life for individuals with DS by understanding which subsets of Hsa21 genes contribute to DS-associated phenotypes throughout the lifetime. However, the complexity of DS pathogenesis has made developing appropriate animal models an ongoing challenge. Here, we examine lessons learned from a variety of model systems, including yeast, nematode, fruit fly, and zebrafish, and discuss emerging methods for creating murine models that better reflect the genetic basis of trisomy 21.",
keywords = "Down syndrome, aneuploidy, complex disease, disease models, model organisms, trisomy 21",
author = "Moyer, {Anna J.} and Katheleen Gardiner and Reeves, {Roger H.}",
note = "Funding Information: This work is supported in part by Public Health Service, United States awards HD038384 , HD098540 and U54HD079123-01A1 (R.H.R.); and by T32GM07814 and 1F31HD098826-01 (A.J.M.). All conclusions are the authors{\textquoteright} own and do not necessarily reflect those of the National Institutes of Health. Figures created with Biorender.com . Funding Information: This work is supported in part by Public Health Service, United States awards HD038384, HD098540 and U54HD079123-01A1 (R.H.R.); and by T32GM07814 and 1F31HD098826-01 (A.J.M.). All conclusions are the authors? own and do not necessarily reflect those of the National Institutes of Health. Figures created with Biorender.com. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2021",
month = may,
doi = "10.1016/j.tig.2020.09.017",
language = "English (US)",
volume = "37",
pages = "444--459",
journal = "Trends in Genetics",
issn = "0168-9525",
publisher = "Elsevier Limited",
number = "5",
}