TY - JOUR
T1 - Alcohol consumption and the risk of nasopharyngeal carcinoma
T2 - A systematic review
AU - Chen, Liwei
AU - Gallicchio, Lisa
AU - Boyd-Lindsley, Kristina
AU - Tao, Xuguang
AU - Robinson, Karen A.
AU - Lam, Tram Kim
AU - Herman, James G.
AU - Caulfield, Laura E.
AU - Guallar, Eliseo
AU - Alberg, Anthony J.
N1 - Funding Information:
This research was made possible through the support of the World Cancer Research Fund. Sources of additional support were the U.S. National Institute of Aging (5U01AG018033) and the National Cancer Institute (CA105069, 5U01CA086308).
Funding Information:
This study was conducted as a part of a project entitled “Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective,” which was funded by the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR). All of the work (including this study) funded under this project was conducted using a WCRF standardized protocol (http://www.wcrf.org/research/second wcrf aicr report.lasso). However, the conclusions of this study may differ from those in the WCRF’s report because the WCRF applied different evaluation criteria in their report.
PY - 2009/1
Y1 - 2009/1
N2 - The evidence concerning the influence of alcohol drinking on the risk of nasopharyngeal carcinoma (NPC) has yielded intriguing findings but has lacked a clear-cut interpretation due to inconsistencies. To unify this body of evidence, we performed a systematic review. With funding and using a protocol developed by the World Cancer Research Fund (WCRF), 15 bibliographic databases were searched for epidemiological studies that reported a measure of association between alcoholic beverage consumption and NPC. Pooled odds ratios (ORs) for highest-vs.-lowest categories of total alcohol intake was obtained by using an inverse-variance weighted random-effects model. A dose-response trend was examined in models using generalized least square estimation. The search identified 14 case-control studies from 5 countries. For total alcohol intake, the pooled ORs in a comparison of the highest to the lowest category was 1.33 (95% CI: = 1.09-1.62) in 11 studies. Data from 6 studies indicated a J-shape dose-response trend, with NPC risk decreasing with up to 15 drinks/wk and increasing with higher intake. Fewer data were available to assess the associations between NPC and intake of beer, wine, and spirits. The potential J-shaped dose-response trend suggests a reduced risk of NPC related to the light alcohol drinking, an observation that warrants further study. Considered in total, the quantitative summaries of the case-control evidence suggest that heavy alcohol consumption is associated with an increased risk of NPC.
AB - The evidence concerning the influence of alcohol drinking on the risk of nasopharyngeal carcinoma (NPC) has yielded intriguing findings but has lacked a clear-cut interpretation due to inconsistencies. To unify this body of evidence, we performed a systematic review. With funding and using a protocol developed by the World Cancer Research Fund (WCRF), 15 bibliographic databases were searched for epidemiological studies that reported a measure of association between alcoholic beverage consumption and NPC. Pooled odds ratios (ORs) for highest-vs.-lowest categories of total alcohol intake was obtained by using an inverse-variance weighted random-effects model. A dose-response trend was examined in models using generalized least square estimation. The search identified 14 case-control studies from 5 countries. For total alcohol intake, the pooled ORs in a comparison of the highest to the lowest category was 1.33 (95% CI: = 1.09-1.62) in 11 studies. Data from 6 studies indicated a J-shape dose-response trend, with NPC risk decreasing with up to 15 drinks/wk and increasing with higher intake. Fewer data were available to assess the associations between NPC and intake of beer, wine, and spirits. The potential J-shaped dose-response trend suggests a reduced risk of NPC related to the light alcohol drinking, an observation that warrants further study. Considered in total, the quantitative summaries of the case-control evidence suggest that heavy alcohol consumption is associated with an increased risk of NPC.
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U2 - 10.1080/01635580802372633
DO - 10.1080/01635580802372633
M3 - Review article
C2 - 19116871
AN - SCOPUS:58149144407
SN - 0163-5581
VL - 61
SP - 1
EP - 15
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 1
ER -