Aging of mesenchymal stem cells: Implication in regenerative medicine

Yueh Hsun Kevin Yang

doi:10.1016/j.reth.2018.09.002

Aging of mesenchymal stem cells: Implication in regenerative medicine

Yueh Hsun Kevin Yang

Research output: Contribution to journal › Comment/debate › peer-review

28 Scopus citations

Abstract

Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs.

Original language	English (US)
Pages (from-to)	120-122
Number of pages	3
Journal	Regenerative Therapy
Volume	9
DOIs	https://doi.org/10.1016/j.reth.2018.09.002
State	Published - Dec 2018
Externally published	Yes

Keywords

Aging
Differentiation
Mesenchymal stem cell
Proliferation
Regenerative medicine
Senescence

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Developmental Biology

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10.1016/j.reth.2018.09.002

Cite this

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title = "Aging of mesenchymal stem cells: Implication in regenerative medicine",

abstract = "Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs.",

keywords = "Aging, Differentiation, Mesenchymal stem cell, Proliferation, Regenerative medicine, Senescence",

author = "Yang, {Yueh Hsun Kevin}",

note = "Publisher Copyright: {\textcopyright} 2018 The Japanese Society for Regenerative Medicine",

year = "2018",

month = dec,

doi = "10.1016/j.reth.2018.09.002",

language = "English (US)",

volume = "9",

pages = "120--122",

journal = "Regenerative Therapy",

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T1 - Aging of mesenchymal stem cells

T2 - Implication in regenerative medicine

AU - Yang, Yueh Hsun Kevin

PY - 2018/12

Y1 - 2018/12

N2 - Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs.

AB - Multipotent mesenchymal stem cells (MSCs) represent a great candidate for various clinical applications including regenerative medicine. However, aging both in vivo and in vitro can significantly compromise MSC characteristics and performance. This paper highlights current thoughts on senescence-induced damage to MSCs that should be considered prior to their use for regeneration of different cells, tissues or organs.

KW - Aging

KW - Differentiation

KW - Mesenchymal stem cell

KW - Proliferation

KW - Regenerative medicine

KW - Senescence

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U2 - 10.1016/j.reth.2018.09.002

DO - 10.1016/j.reth.2018.09.002

M3 - Comment/debate

AN - SCOPUS:85055799936

SN - 2352-3204

VL - 9

SP - 120

EP - 122

JO - Regenerative Therapy

JF - Regenerative Therapy

ER -

Aging of mesenchymal stem cells: Implication in regenerative medicine

Abstract

Keywords

ASJC Scopus subject areas

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