TY - JOUR
T1 - Aging Increases Susceptibility to Ovarian Cancer Metastasis in Murine Allograft Models and Alters Immune Composition of Peritoneal Adipose Tissue
AU - Loughran, Elizabeth A.
AU - Leonard, Annemarie K.
AU - Hilliard, Tyvette S.
AU - Phan, Ryan C.
AU - Yemc, Madeleine G.
AU - Harper, Elizabeth
AU - Sheedy, Emma
AU - Klymenko, Yuliya
AU - Asem, Marwa
AU - Liu, Yueying
AU - Yang, Jing
AU - Johnson, Jeff
AU - Tarwater, Laura
AU - Shi, Zonggao
AU - Leevy, Matthew
AU - Ravosa, Matthew J.
AU - Stack, M. Sharon
N1 - Funding Information:
This work was supported by Grants RO1CA109545 (MSS) from the National Institutes of Health/National Cancer Institute; from the Leo and Anne Albert Charitable Trust (MSS); National Science Foundation Graduate Research Fellowship Program grant DGE-1313583 (EAL); National Institutes of Health/National Cancer Institute KO1 CA218305 (TSH). We thank Freimann Life Sciences Center at the University of Notre Dame, especially Emily Cronberger, for their care of the mice and contributions to the breeding strategy. Appendix A
Publisher Copyright:
© 2018 The Authors
PY - 2018/6
Y1 - 2018/6
N2 - Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis. Here we report that the aged host is more susceptible to metastatic success using two murine syngeneic allograft models of ovarian cancer metastasis. This age-related increase in metastatic tumor burden corresponds with an increase in tumor infiltrating lymphocytes (TILs) in tumor-bearing mice and alteration of B cell-related pathways in gonadal adipose tissue. Based on this work, further studies elucidating the status of B cell TILs in mouse models of metastasis and human tumors in the context of aging are warranted.
AB - Ovarian cancer, the most deadly gynecological malignancy in U.S. women, metastasizes uniquely, spreading through the peritoneal cavity and often generating widespread metastatic sites before diagnosis. The vast majority of ovarian cancer cases occur in women over 40 and the median age at diagnosis is 63. Additionally, elderly women receive poorer prognoses when diagnosed with ovarian cancer. Despite age being a significant risk factor for the development of this cancer, there are little published data which address the impact of aging on ovarian cancer metastasis. Here we report that the aged host is more susceptible to metastatic success using two murine syngeneic allograft models of ovarian cancer metastasis. This age-related increase in metastatic tumor burden corresponds with an increase in tumor infiltrating lymphocytes (TILs) in tumor-bearing mice and alteration of B cell-related pathways in gonadal adipose tissue. Based on this work, further studies elucidating the status of B cell TILs in mouse models of metastasis and human tumors in the context of aging are warranted.
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U2 - 10.1016/j.neo.2018.03.007
DO - 10.1016/j.neo.2018.03.007
M3 - Article
C2 - 29754071
AN - SCOPUS:85046804656
SN - 1522-8002
VL - 20
SP - 621
EP - 631
JO - Neoplasia
JF - Neoplasia
IS - 6
ER -