Aging effects on drug disposition and effect

D. R. Abernethy

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Drug therapy in older individuals has generally been summarized in the phrase 'start low and go slow'. As better understanding of the effects and disposition of drugs in the aged has evolved, the concept of 'therapeutic burden' which encompasses the number of concurrent medications as well as the dose of medications administered has assumed considerable importance. Epidemiologic and surveillance data demonstrate that drug therapy, in addition to offering improvement in quality and quantity of life, is also a major source of morbidity for the aged patient. These data and advances in understanding the pathophysiology of aging for individual patients which contribute to understanding of age related changes in drug response are discussed.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalGeriatric Nephrology and Urology
Issue number1
StatePublished - 1999
Externally publishedYes


  • Aging
  • Creatinine clearance
  • Drug deposition
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Nephrology
  • Urology


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