Aging-associated B7-DC + B cells enhance anti-tumor immunity via Th1 and Th17 induction

Kei Tomihara, Takako Shin, Vincent J. Hurez, Hideo Yagita, Drew M. Pardoll, Bin Zhang, Tyler J. Curiel, Tahiro Shin

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for aging-associated immunological alterations in the design of new cancer immunotherapies. We thus compared immune populations in young and aged mice and found that B7-DC + (PD-L2/CD273) B cells, a minor population in young mice, were significantly increased in aged mice. Induction of both Th1 and Th17 cells was significantly augmented by B7-DC + B cells from aged mice, and this effect was blocked with anti-B7-DC antibodies in vitro and in vivo. Moreover, retardation of tumor growth in aged mice was largely B7-DC dependent. Tumor growth in young mice was significantly inhibited by immunization with B7-DC + B cells from aged mice owing to increased induction of tumor antigen-specific cytotoxic T lymphocytes. These data indicate that B7-DC + B cells could play an important role in aging-associated cancer immunopathology as well as in other aging-associated diseases and further suggest that B7-DC + B cells have potential for future cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)128-138
Number of pages11
JournalAging Cell
Issue number1
StatePublished - Feb 2012


  • Antitumor immunity
  • B cell
  • B7-DC
  • Co-stimulation
  • Cytotoxic T lymphocyte
  • PD-L2
  • Th17

ASJC Scopus subject areas

  • Aging
  • Cell Biology


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