TY - JOUR
T1 - Age-related vascular stiffness and left ventricular size after myocardial infarction
AU - Hirsch, Glenn A.
AU - Ingkanisorn, W. Patricia
AU - Schulman, Steven P.
AU - Gerstenblith, Gary
AU - Dyke, Christopher K.
AU - Rhoads, Kenneth L.
AU - Thompson, Richard
AU - Aletras, Anthony H.
AU - Arai, Andrew E.
PY - 2007/7
Y1 - 2007/7
N2 - Aortic stiffness increases with age and may contribute to adverse remodeling after myocardial infarction (MI). The authors examined whether vascular stiffness affects left ventricular (LV) size after MI using contrast-enhanced cardiac magnetic resonance imaging. Despite similar infarct sizes, patients aged 60 years or older (n=30) had a lower ejection fraction (42±15 vs 53±11%, P<.01) and greater end-systolic volume index (75±47 vs 44±18 mL/m2, P<.01) than younger patients (n=19). As infarct size increased, LV end-systolic volumes (P<.0001) and ejection fraction (P<.0001) in the older participants were progressively greater. Participants with greater aortic stiffness had greater end-systolic volume indices (P<.0001) and lower ejection fraction (P<.0001) with increasing infarct size. Using multivariate analysis, MI size (P<.001) and aortic distensibility (P=.02) were significant predictors of end-systolic volume index. Older patients have increased LV size after MI compared with younger patients, possibly related to age-related decreases in aortic distensibility affecting LV remodeling.
AB - Aortic stiffness increases with age and may contribute to adverse remodeling after myocardial infarction (MI). The authors examined whether vascular stiffness affects left ventricular (LV) size after MI using contrast-enhanced cardiac magnetic resonance imaging. Despite similar infarct sizes, patients aged 60 years or older (n=30) had a lower ejection fraction (42±15 vs 53±11%, P<.01) and greater end-systolic volume index (75±47 vs 44±18 mL/m2, P<.01) than younger patients (n=19). As infarct size increased, LV end-systolic volumes (P<.0001) and ejection fraction (P<.0001) in the older participants were progressively greater. Participants with greater aortic stiffness had greater end-systolic volume indices (P<.0001) and lower ejection fraction (P<.0001) with increasing infarct size. Using multivariate analysis, MI size (P<.001) and aortic distensibility (P=.02) were significant predictors of end-systolic volume index. Older patients have increased LV size after MI compared with younger patients, possibly related to age-related decreases in aortic distensibility affecting LV remodeling.
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U2 - 10.1111/j.1076-7460.2007.05849.x
DO - 10.1111/j.1076-7460.2007.05849.x
M3 - Article
C2 - 17617748
AN - SCOPUS:35248817872
SN - 1076-7460
VL - 16
SP - 222
EP - 228
JO - American Journal of Geriatric Cardiology
JF - American Journal of Geriatric Cardiology
IS - 4
ER -