Age-related effects of compression rate and duration in cardiopulmonary resuscitation

J. M. Dean, R. C. Koehler, C. L. Schleien, I. Berkowitz, J. R. Michael, D. Atchison, M. C. Rogers, R. J. Traystman

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The effects of various compression rate and duration combinations on chest geometry and cerebral perfusion pressure during cardiopulmonary resuscitation (CPR) were studied in immature swine. Pentobarbital-anesthetized 2- and 8-wk-old piglets received CPR after ventricular fibrillation. At compression rates of 40, 60, 80, 100, 120, and 150/min, duty cycle (compression duration/total cycle time) was increased from 10 to 80% by 10% increments. Mean aortic and sagittal sinus pressures, pulsatile displacement, and deformity of the anterior chest wall were measured. Increasing duty cycle increased cerebral perfusion pressure until chest relaxation time was compromised. Inadequate chest recoil, development of static chest deformation, and limitation of pulsatile chest wall movement occurred in both age groups when relaxation time was very short (150-200 ms in 2-wk-old piglets, 250-300 ms in 8-wk-old piglets). These changes in chest geometry correlated with deterioration of cerebral perfusion pressure only in 8-wk-old piglets. In the younger group, perfusion pressures plateaued but did not deteriorate. These data emphasize the importance of duty cycle in generating cerebral perfusion pressure and indicate that younger animals can tolerate high compression rates except at extremely long duty cycles.

Original languageEnglish (US)
Pages (from-to)554-560
Number of pages7
JournalJournal of applied physiology
Issue number2
StatePublished - 1990
Externally publishedYes


  • cerebral perfusion pressure
  • chest geometry
  • chest wall mechanics
  • infants
  • swine

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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