Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus

Edith V. Sullivan, Laura Marsh, Daniel H. Mathalon, Kelvin O. Lim, Adolf Pfefferbaum

Research output: Contribution to journalArticlepeer-review

225 Scopus citations


The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly correlated with age. By contrast, left and right temporal lobe gray matter volumes, exclusive of the hippocampal measures, each decreased with age (p <0.01). Volumes of temporal lobe sulcal CSF and the ventricular system (temporal horns and lateral and third ventricles) significantly increased with age. Measures of verbal and nonverbal working memory showed age-related declines and were related to enlargement of the three ventricular regions, which may be indicative of age-related atrophy of the adjacent cortex but not the hippocampus, at least up to age 70 years.

Original languageEnglish (US)
Pages (from-to)591-606
Number of pages16
JournalNeurobiology of Aging
Issue number4
StatePublished - 1995
Externally publishedYes


  • Aging
  • Gray matter
  • Hippocampus
  • Memory
  • Temporal lobes
  • Ventricles
  • White matter

ASJC Scopus subject areas

  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neuroscience(all)
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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