Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A 1H MRS Study at 7 Tesla

Allison S. Brandt, Paul G. Unschuld, Subechhya Pradhan, Issel Anne L. Lim, Gregory Churchill, Ashley D. Harris, Jun Hua, Peter B. Barker, Christopher A. Ross, Peter C.M. van Zijl, Richard A.E. Edden, Russell L. Margolis

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalSchizophrenia Research
Issue number1-3
StatePublished - Apr 1 2016


  • 7 T
  • Anterior cingulate cortex
  • Glutamate
  • Magnetic resonance spectroscopy
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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