Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A 1H MRS Study at 7 Tesla

Allison S. Brandt; Paul G. Unschuld; Subechhya Pradhan; Issel Anne L. Lim; Gregory Churchill; Ashley D. Harris; Jun Hua; Peter B. Barker; Christopher A. Ross; Peter C.M. van Zijl; Richard A.E. Edden; Russell L. Margolis

doi:10.1016/j.schres.2016.02.017

Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A ¹H MRS Study at 7 Tesla

Allison S. Brandt, Paul G. Unschuld, Subechhya Pradhan, Issel Anne L. Lim, Gregory Churchill, Ashley D. Harris, Jun Hua, Peter B. Barker, Christopher A. Ross, Peter C.M. van Zijl, Richard A.E. Edden, Russell L. Margolis

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.

Original language	English (US)
Pages (from-to)	101-105
Number of pages	5
Journal	Schizophrenia Research
Volume	172
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2016.02.017
State	Published - Apr 1 2016

Keywords

7 T
Anterior cingulate cortex
Glutamate
Magnetic resonance spectroscopy
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/j.schres.2016.02.017

Cite this

Brandt, A. S., Unschuld, P. G., Pradhan, S., Lim, I. A. L., Churchill, G., Harris, A. D., Hua, J., Barker, P. B., Ross, C. A., van Zijl, P. C. M., Edden, R. A. E., & Margolis, R. L. (2016). Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A ¹H MRS Study at 7 Tesla. Schizophrenia Research, 172(1-3), 101-105. https://doi.org/10.1016/j.schres.2016.02.017

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abstract = "The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.",

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author = "Brandt, {Allison S.} and Unschuld, {Paul G.} and Subechhya Pradhan and Lim, {Issel Anne L.} and Gregory Churchill and Harris, {Ashley D.} and Jun Hua and Barker, {Peter B.} and Ross, {Christopher A.} and {van Zijl}, {Peter C.M.} and Edden, {Richard A.E.} and Margolis, {Russell L.}",

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AU - Lim, Issel Anne L.

AU - Churchill, Gregory

AU - Harris, Ashley D.

AU - Hua, Jun

AU - Barker, Peter B.

AU - Ross, Christopher A.

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AU - Edden, Richard A.E.

AU - Margolis, Russell L.

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AB - The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.

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