Age-related alterations in the genetics and genomics of the male germ line

Amin S. Herati, Boryana H. Zhelyazkova, Peter R. Butler, Dolores J. Lamb

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalFertility and sterility
Issue number2
StatePublished - Feb 1 2017
Externally publishedYes


  • Genetics
  • humans
  • male
  • paternal age
  • reproduction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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