Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico

Leonardo S. Lino-Silva; Martín Lajous; Marion Brochier; Luis Santiago-Ruiz; Javier Melchor-Ruan; Yi Xie; Mingyi Wang; Dongjing Wu; Herbert Higson; Kristine Jones; Martin Romero-Martínez; Salvador Villalpando; Alejandro Mohar; Joshua W. Smith; Christian S. Alvarez; Katherine A. McGlynn; Michael Dean; John Groopman

doi:10.21149/13189

Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico

Leonardo S. Lino-Silva, Martín Lajous, Marion Brochier, Luis Santiago-Ruiz, Javier Melchor-Ruan, Yi Xie, Mingyi Wang, Dongjing Wu, Herbert Higson, Kristine Jones, Martin Romero-Martínez, Salvador Villalpando, Alejandro Mohar, Joshua W. Smith, Christian S. Alvarez, Katherine A. McGlynn, Michael Dean, John Groopman

Research output: Contribution to journal › Article › peer-review

Abstract

Objective. To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods. We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results. The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/μL (IQR, 0.050–0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion.

Original language	English (US)
Pages (from-to)	35-40
Number of pages	6
Journal	Salud Publica de Mexico
Volume	64
Issue number	1
DOIs	https://doi.org/10.21149/13189
State	Published - 2022
Externally published	Yes

Keywords

Aflatoxin b1
Environmental biomarkers
Epidemiology
Liver neoplasia
Mutation
Mycotoxin

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.21149/13189

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Lino-Silva, L. S., Lajous, M., Brochier, M., Santiago-Ruiz, L., Melchor-Ruan, J., Xie, Y., Wang, M., Wu, D., Higson, H., Jones, K., Romero-Martínez, M., Villalpando, S., Mohar, A., Smith, J. W., Alvarez, C. S., McGlynn, K. A., Dean, M., & Groopman, J. (2022). Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico. Salud Publica de Mexico, 64(1), 35-40. https://doi.org/10.21149/13189

Lino-Silva, LS, Lajous, M, Brochier, M, Santiago-Ruiz, L, Melchor-Ruan, J, Xie, Y, Wang, M, Wu, D, Higson, H, Jones, K, Romero-Martínez, M, Villalpando, S, Mohar, A, Smith, JW, Alvarez, CS, McGlynn, KA, Dean, M & Groopman, J 2022, 'Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico', Salud Publica de Mexico, vol. 64, no. 1, pp. 35-40. https://doi.org/10.21149/13189

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title = "Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico",

abstract = "Objective. To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods. We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results. The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/μL (IQR, 0.050–0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion.",

keywords = "Aflatoxin b1, Environmental biomarkers, Epidemiology, Liver neoplasia, Mutation, Mycotoxin",

author = "Lino-Silva, {Leonardo S.} and Mart{\'i}n Lajous and Marion Brochier and Luis Santiago-Ruiz and Javier Melchor-Ruan and Yi Xie and Mingyi Wang and Dongjing Wu and Herbert Higson and Kristine Jones and Martin Romero-Mart{\'i}nez and Salvador Villalpando and Alejandro Mohar and Smith, {Joshua W.} and Alvarez, {Christian S.} and McGlynn, {Katherine A.} and Michael Dean and John Groopman",

note = "Funding Information: This research was funded by the US National Cancer Institute{\textquoteright}s Intramural Research program and grant P20CA210286. The content is solely the responsibility of the authors and does not necessarily represent the o 耀cial views of the National Cancer Institute. Publisher Copyright: {\textcopyright} 2022,Salud Publica de Mexico.All Rights Reserved",

year = "2022",

doi = "10.21149/13189",

language = "English (US)",

volume = "64",

pages = "35--40",

journal = "Salud Publica de Mexico",

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T1 - Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico

AU - Lino-Silva, Leonardo S.

AU - Lajous, Martín

AU - Brochier, Marion

AU - Santiago-Ruiz, Luis

AU - Melchor-Ruan, Javier

AU - Xie, Yi

AU - Wang, Mingyi

AU - Wu, Dongjing

AU - Higson, Herbert

AU - Jones, Kristine

AU - Romero-Martínez, Martin

AU - Villalpando, Salvador

AU - Mohar, Alejandro

AU - Smith, Joshua W.

AU - Alvarez, Christian S.

AU - McGlynn, Katherine A.

AU - Dean, Michael

AU - Groopman, John

N1 - Funding Information: This research was funded by the US National Cancer Institute’s Intramural Research program and grant P20CA210286. The content is solely the responsibility of the authors and does not necessarily represent the o 耀cial views of the National Cancer Institute. Publisher Copyright: © 2022,Salud Publica de Mexico.All Rights Reserved

PY - 2022

Y1 - 2022

N2 - Objective. To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods. We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results. The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/μL (IQR, 0.050–0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion.

AB - Objective. To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods. We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results. The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/μL (IQR, 0.050–0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion.

KW - Aflatoxin b1

KW - Environmental biomarkers

KW - Epidemiology

KW - Liver neoplasia

KW - Mutation

KW - Mycotoxin

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Aflatoxin levels and prevalence of TP53 aflatoxin-mutations in hepatocellular carcinomas in Mexico

Abstract

Keywords

ASJC Scopus subject areas

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