Aerosol Immunization of Humans with Inactivated Parainfluenza Type 2 Vaccine

F. M. Wigley; M. H. Fruchtman; R. H. Waldman

doi:10.1056/NEJM197012032832303

Aerosol Immunization of Humans with Inactivated Parainfluenza Type 2 Vaccine

F. M. Wigley, M. H. Fruchtman, R. H. Waldman

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11 Scopus citations

Abstract

The antibody response was compared in 40 volunteers who were immunized with parainfluenza Type 2 vaccine, either subcutaneously or by aerosol, and in 16 controls. The neutralizing-antibody response in respiratory secretions was of greater magnitude in the aerosol group than in the other groups. In both the aerosol and the subcutaneous groups there was a significant rise in serum antibody. The respiratory-secretion antibody was found in the IgA class.

Original language	English (US)
Pages (from-to)	1250-1253
Number of pages	4
Journal	New England Journal of Medicine
Volume	283
Issue number	23
DOIs	https://doi.org/10.1056/NEJM197012032832303
State	Published - Dec 3 1970
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM197012032832303

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title = "Aerosol Immunization of Humans with Inactivated Parainfluenza Type 2 Vaccine",

abstract = "The antibody response was compared in 40 volunteers who were immunized with parainfluenza Type 2 vaccine, either subcutaneously or by aerosol, and in 16 controls. The neutralizing-antibody response in respiratory secretions was of greater magnitude in the aerosol group than in the other groups. In both the aerosol and the subcutaneous groups there was a significant rise in serum antibody. The respiratory-secretion antibody was found in the IgA class.",

author = "Wigley, {F. M.} and Fruchtman, {M. H.} and Waldman, {R. H.}",

year = "1970",

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AU - Waldman, R. H.

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Y1 - 1970/12/3

N2 - The antibody response was compared in 40 volunteers who were immunized with parainfluenza Type 2 vaccine, either subcutaneously or by aerosol, and in 16 controls. The neutralizing-antibody response in respiratory secretions was of greater magnitude in the aerosol group than in the other groups. In both the aerosol and the subcutaneous groups there was a significant rise in serum antibody. The respiratory-secretion antibody was found in the IgA class.

AB - The antibody response was compared in 40 volunteers who were immunized with parainfluenza Type 2 vaccine, either subcutaneously or by aerosol, and in 16 controls. The neutralizing-antibody response in respiratory secretions was of greater magnitude in the aerosol group than in the other groups. In both the aerosol and the subcutaneous groups there was a significant rise in serum antibody. The respiratory-secretion antibody was found in the IgA class.

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Aerosol Immunization of Humans with Inactivated Parainfluenza Type 2 Vaccine

Abstract

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