TY - JOUR
T1 - Aerobic exercise modulates the free fatty acids and inflammatory response during obesity and cancer cachexia
AU - Teixeira, Alexandre Abilio de S.
AU - Lira, Fábio S.
AU - Pimentel, Gustavo D.
AU - Oliveira de Souza, Camila
AU - Batatinha, Helena
AU - Biondo, Luana A.
AU - Yamashita, Alex S.
AU - Lima Júnior, Edson A.
AU - Rosa Neto, José C.
N1 - Funding Information:
To Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Brazil) process number 2013/09367-4, 2013/25310-2 and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil) by funding sources.
Publisher Copyright:
© 2016 Begell House, Inc.
PY - 2016
Y1 - 2016
N2 - White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia.
AB - White adipose tissue (WAT) is no longer considered a tissue whose main function is the storage of TAG. Since the discovery of leptin in 1994, several studies have elucidated the important role of WAT as an endocrine organ, the source of the adipokines. The low-grade inflammation observed in obese and cancer cachexia patients is explained, at least partially, by the exacerbated release of proinflammatory adipokines. Despite of the recent progress in the characterization of the various adipokines and lipokines produced by WAT, little is known about the mechanisms regulating the secretion of these molecules in different physiological and pathological circumstances. Chronic exercise is a nonpharmacological therapy employed in several chronic diseases and shows an anti-inflammatory effect through the regulation of the cytokine network. In this review, we address the potential mechanisms by which the aerobic physical exercise modulate the production and release of inflammatory adipokines, as well as the inflammation-lipolysis axis in WAT, with special focus in the therapeutic role of exercise in obesity-associated insulin resistance and cancer cachexia.
KW - Aerobic exercise
KW - Cancer cachexia
KW - Inflammation
KW - Obesity
KW - White adipose tissue
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U2 - 10.1615/CritRevEukaryotGeneExpr.2016016490
DO - 10.1615/CritRevEukaryotGeneExpr.2016016490
M3 - Article
C2 - 27650984
AN - SCOPUS:84989834037
SN - 1045-4403
VL - 26
SP - 187
EP - 198
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
IS - 3
ER -