Advances in understanding the development of the nervous system

H. S. Singer, A. Y. Chiu, F. K. Meiri, P. Morell, P. G. Nelson, G. Tennekoon

Research output: Contribution to journalEditorialpeer-review

12 Scopus citations


Over the past several years remarkable progress has been made towards unraveling the complex mechanisms that regulate neuronal development. Because the end results of abnormalities in brain development are often developmental disabilities, it is timely to review several recent advances in the field of neurobiology. This review, with contributions from several co-authors, provides a synopsis of breakthroughs from the fields of embryology, cell biology, and molecular genetics that hold promise for exciting clinical application. This article is arranged to reflect the stages of normal development. Understanding the mechanisms underlying neuronal induction, regional specification, neuronal specification, migration, axonal growth, neurotrophic factors, and myelination should clarify the pathophysiology of numerous neurological disorders, and provide new insights into their treatment.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalCurrent opinion in neurology
Issue number2
StatePublished - 1994

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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