Advances in Understanding Air Pollution and CVD

Joel D. Kaufman, Elizabeth W. Spalt, Cynthia L. Curl, Anjum Hajat, Miranda R. Jones, Sun Young Kim, Sverre Vedal, Adam A. Szpiro, Amanda Gassett, Lianne Sheppard, Martha L. Daviglus, Sara D. Adar

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


The MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution) leveraged the platform of the MESA cohort into a prospective longitudinal study of relationships between air pollution and cardiovascular health. MESA Air researchers developed fine-scale, state-of-the-art air pollution exposure models for the MESA Air communities, creating individual exposure estimates for each participant. These models combine cohort-specific exposure monitoring, existing monitoring systems, and an extensive database of geographic and meteorological information. Together with extensive phenotyping in MESA—and adding participants and health measurements to the cohort—MESA Air investigated environmental exposures on a wide range of outcomes. Advances by the MESA Air team included not only a new approach to exposure modeling, but also biostatistical advances in addressing exposure measurement error and temporal confounding. The MESA Air study advanced our understanding of the impact of air pollutants on cardiovascular disease and provided a research platform for advances in environmental epidemiology.

Original languageEnglish (US)
Pages (from-to)343-352
Number of pages10
JournalGlobal Heart
Issue number3
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Epidemiology
  • Community and Home Care
  • Cardiology and Cardiovascular Medicine


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