Advances in synthetic peptide immuno-regulatory epitopes

Peter Socrates Creticos

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Synthetic peptide immuno-regulatory epitopes (SPIRE) represent a new class of therapeutics for allergen immunotherapy that offer the potential to suppress the IgE-mediated allergic disease process through induction of T-cell tolerance. These synthetic T-cell-tolerizing peptides have been designed to induce immunologic tolerance via binding to MHC class II molecules on antigen presenting cells, with subsequent upregulation of regulatory T-cells.

Original languageEnglish (US)
Article number30
JournalWorld Allergy Organization Journal
Issue number1
StatePublished - 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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