Advances in skeletal tissue engineering with hydrogels

J. Elisseeff, C. Puleo, F. Yang, B. Sharma

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Objectives : Tissue engineering has the potential to make a significant impact on improving tissue repair in the craniofacial system. The general strategy for tissue engineering includes seeding cells on a biomaterial scaffold. The number of scaffold and cell choices for tissue engineering systems is continually increasing and will be reviewed. Design : Multilayered hydrogel systems were developed to coculture different cell types and develop osteochondral tissues for applications including the temporomandibular joint. Experimental variable-Hydrogels are one form of scaffold that can be applied to cartilage and bone repair using fully differentiated cells, adult and embryonic stem cells. Outcome measure-Case studies represent an overview of our laboratory's investigations. Result : Bilayered scaffolds to promote tissue development and the formation of more complex osteochondral tissues were developed and proved to be effective. Conclusion : Tissue engineering provides a venue to investigate tissue development of mutant or diseased cells and potential therapeutics.

Original languageEnglish (US)
Pages (from-to)150-161
Number of pages12
JournalOrthodontics and Craniofacial Research
Issue number3
StatePublished - 2005


  • Hydrogels
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Orthodontics
  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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