Advances in nucleic acid architectures for electrochemical sensing

Research output: Contribution to journalReview articlepeer-review


Nucleic acid–based electrochemical sensors are ideally suited to the detection of molecular targets for which enzymatic detection or direct electrochemical oxidation – reduction reactions are not possible. Moreover, the versatility of nucleic acids in their ability to bind a great variety of target types, from small molecules to single-entity mesoscopic targets, makes them attractive receptors for the development of electrochemical biosensors. In this brief opinion piece, we discuss field advances from the past two years. We hope the works highlighted here will inspire the community to pursue creative designs enabling the detection of larger and more complex targets with a specific focus on analytical validation and translation into preclinical or clinical applications.

Original languageEnglish (US)
Article number100695
JournalCurrent Opinion in Electrochemistry
StatePublished - Jun 2021


  • Clinical validation
  • DNA biosensors
  • DNA origami
  • DNA tetrahedral frameworks
  • Electrochemical sensors

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry


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