Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations

Robert H. Dworkin; Miroslav Backonja; Michael C. Rowbotham; Robert R. Allen; Charles R. Argoff; Gary J. Bennett; M. Catherine Bushnell; John T. Farrar; Bradley S. Galer; Jennifer A. Haythornthwaite; David J. Hewitt; John D. Loeser; Mitchell B. Max; Mario Saltarelli; Kenneth E. Schmader; Christoph Stein; David Thompson; Dennis C. Turk; Mark S. Wallace; Linda R. Watkins; Sharon M. Weinstein

doi:10.1001/archneur.60.11.1524

Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations

Robert H. Dworkin, Miroslav Backonja, Michael C. Rowbotham, Robert R. Allen, Charles R. Argoff, Gary J. Bennett, M. Catherine Bushnell, John T. Farrar, Bradley S. Galer, Jennifer A. Haythornthwaite, David J. Hewitt, John D. Loeser, Mitchell B. Max, Mario Saltarelli, Kenneth E. Schmader, Christoph Stein, David Thompson, Dennis C. Turk, Mark S. Wallace, Linda R. WatkinsSharon M. Weinstein

Research output: Contribution to journal › Review article › peer-review

997 Scopus citations

Abstract

Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

Original language	English (US)
Pages (from-to)	1524-1534
Number of pages	11
Journal	Archives of neurology
Volume	60
Issue number	11
DOIs	https://doi.org/10.1001/archneur.60.11.1524
State	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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Dworkin, R. H., Backonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C. R., Bennett, G. J., Bushnell, M. C., Farrar, J. T., Galer, B. S., Haythornthwaite, J. A., Hewitt, D. J., Loeser, J. D., Max, M. B., Saltarelli, M., Schmader, K. E., Stein, C., Thompson, D., Turk, D. C., Wallace, M. S., ... Weinstein, S. M. (2003). Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations. Archives of neurology, 60(11), 1524-1534. https://doi.org/10.1001/archneur.60.11.1524

Dworkin, RH, Backonja, M, Rowbotham, MC, Allen, RR, Argoff, CR, Bennett, GJ, Bushnell, MC, Farrar, JT, Galer, BS, Haythornthwaite, JA, Hewitt, DJ, Loeser, JD, Max, MB, Saltarelli, M, Schmader, KE, Stein, C, Thompson, D, Turk, DC, Wallace, MS, Watkins, LR & Weinstein, SM 2003, 'Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations', Archives of neurology, vol. 60, no. 11, pp. 1524-1534. https://doi.org/10.1001/archneur.60.11.1524

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title = "Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations",

abstract = "Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.",

author = "Dworkin, {Robert H.} and Miroslav Backonja and Rowbotham, {Michael C.} and Allen, {Robert R.} and Argoff, {Charles R.} and Bennett, {Gary J.} and Bushnell, {M. Catherine} and Farrar, {John T.} and Galer, {Bradley S.} and Haythornthwaite, {Jennifer A.} and Hewitt, {David J.} and Loeser, {John D.} and Max, {Mitchell B.} and Mario Saltarelli and Schmader, {Kenneth E.} and Christoph Stein and David Thompson and Turk, {Dennis C.} and Wallace, {Mark S.} and Watkins, {Linda R.} and Weinstein, {Sharon M.}",

year = "2003",

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doi = "10.1001/archneur.60.11.1524",

language = "English (US)",

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AU - Allen, Robert R.

AU - Argoff, Charles R.

AU - Bennett, Gary J.

AU - Bushnell, M. Catherine

AU - Farrar, John T.

AU - Galer, Bradley S.

AU - Haythornthwaite, Jennifer A.

AU - Hewitt, David J.

AU - Loeser, John D.

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AU - Saltarelli, Mario

AU - Schmader, Kenneth E.

AU - Stein, Christoph

AU - Thompson, David

AU - Turk, Dennis C.

AU - Wallace, Mark S.

AU - Watkins, Linda R.

AU - Weinstein, Sharon M.

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AB - Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

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Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations

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