Advances in Neuropathic Pain: Diagnosis, Mechanisms, and Treatment Recommendations

Robert H. Dworkin, Miroslav Backonja, Michael C. Rowbotham, Robert R. Allen, Charles R. Argoff, Gary J. Bennett, M. Catherine Bushnell, John T. Farrar, Bradley S. Galer, Jennifer A. Haythornthwaite, David J. Hewitt, John D. Loeser, Mitchell B. Max, Mario Saltarelli, Kenneth E. Schmader, Christoph Stein, David Thompson, Dennis C. Turk, Mark S. Wallace, Linda R. WatkinsSharon M. Weinstein

Research output: Contribution to journalReview articlepeer-review

997 Scopus citations


Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

Original languageEnglish (US)
Pages (from-to)1524-1534
Number of pages11
JournalArchives of neurology
Issue number11
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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