Advances in monitoring for acute spinal cord injury: a narrative review of current literature

Yohannes Tsehay; Carly Weber-Levine; Timothy Kim; Alejandro Chara; Safwan Alomari; Tolulope Awosika; Ann Liu; Jeffrey Ehresman; Kurt Lehner; Brian Hwang; Andrew M. Hersh; Ian Suk; Eli Curry; Fariba Aghabaglou; Yinuo Zeng; Amir Manbachi; Nicholas Theodore

doi:10.1016/j.spinee.2022.03.012

Advances in monitoring for acute spinal cord injury: a narrative review of current literature

Yohannes Tsehay, Carly Weber-Levine, Timothy Kim, Alejandro Chara, Safwan Alomari, Tolulope Awosika, Ann Liu, Jeffrey Ehresman, Kurt Lehner, Brian Hwang, Andrew M. Hersh, Ian Suk, Eli Curry, Fariba Aghabaglou, Yinuo Zeng, Amir Manbachi, Nicholas Theodore

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Spinal cord injury (SCI) is a devastating condition that affects about 17,000 individuals every year in the United States, with approximately 294,000 people living with the ramifications of the initial injury. After the initial primary injury, SCI has a secondary phase during which the spinal cord sustains further injury due to ischemia, excitotoxicity, immune-mediated damage, mitochondrial dysfunction, apoptosis, and oxidative stress. The multifaceted injury progression process requires a sophisticated injury-monitoring technique for an accurate assessment of SCI patients. In this narrative review, we discuss SCI monitoring modalities, including pressure probes and catheters, micro dialysis, electrophysiologic measures, biomarkers, and imaging studies. The optimal next-generation injury monitoring setup should include multiple modalities and should integrate the data to produce a final simplified assessment of the injury and determine markers of intervention to improve patient outcomes.

Original language	English (US)
Pages (from-to)	1372-1387
Number of pages	16
Journal	Spine Journal
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/j.spinee.2022.03.012
State	Published - Aug 2022

Keywords

Advanced monitoring for spinal cord injury
Artificial intelligence
Biomarkers
Electrophysiology
Imaging
MRI
Machine learning
Spinal cord injury
Ultrasound

ASJC Scopus subject areas

Clinical Neurology
Surgery
Orthopedics and Sports Medicine

Access to Document

10.1016/j.spinee.2022.03.012

Cite this

Tsehay, Y., Weber-Levine, C., Kim, T., Chara, A., Alomari, S., Awosika, T., Liu, A., Ehresman, J., Lehner, K., Hwang, B., Hersh, A. M., Suk, I., Curry, E., Aghabaglou, F., Zeng, Y., Manbachi, A., & Theodore, N. (2022). Advances in monitoring for acute spinal cord injury: a narrative review of current literature. Spine Journal, 22(8), 1372-1387. https://doi.org/10.1016/j.spinee.2022.03.012

Tsehay, Y, Weber-Levine, C, Kim, T, Chara, A, Alomari, S, Awosika, T, Liu, A, Ehresman, J, Lehner, K, Hwang, B, Hersh, AM, Suk, I, Curry, E, Aghabaglou, F, Zeng, Y, Manbachi, A & Theodore, N 2022, 'Advances in monitoring for acute spinal cord injury: a narrative review of current literature', Spine Journal, vol. 22, no. 8, pp. 1372-1387. https://doi.org/10.1016/j.spinee.2022.03.012

@article{63c74e1ea0b542b3bb2576370fd675d3,

title = "Advances in monitoring for acute spinal cord injury: a narrative review of current literature",

abstract = "Spinal cord injury (SCI) is a devastating condition that affects about 17,000 individuals every year in the United States, with approximately 294,000 people living with the ramifications of the initial injury. After the initial primary injury, SCI has a secondary phase during which the spinal cord sustains further injury due to ischemia, excitotoxicity, immune-mediated damage, mitochondrial dysfunction, apoptosis, and oxidative stress. The multifaceted injury progression process requires a sophisticated injury-monitoring technique for an accurate assessment of SCI patients. In this narrative review, we discuss SCI monitoring modalities, including pressure probes and catheters, micro dialysis, electrophysiologic measures, biomarkers, and imaging studies. The optimal next-generation injury monitoring setup should include multiple modalities and should integrate the data to produce a final simplified assessment of the injury and determine markers of intervention to improve patient outcomes.",

keywords = "Advanced monitoring for spinal cord injury, Artificial intelligence, Biomarkers, Electrophysiology, Imaging, MRI, Machine learning, Spinal cord injury, Ultrasound",

author = "Yohannes Tsehay and Carly Weber-Levine and Timothy Kim and Alejandro Chara and Safwan Alomari and Tolulope Awosika and Ann Liu and Jeffrey Ehresman and Kurt Lehner and Brian Hwang and Hersh, {Andrew M.} and Ian Suk and Eli Curry and Fariba Aghabaglou and Yinuo Zeng and Amir Manbachi and Nicholas Theodore",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = aug,

doi = "10.1016/j.spinee.2022.03.012",

language = "English (US)",

volume = "22",

pages = "1372--1387",

journal = "Spine Journal",

issn = "1529-9430",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Advances in monitoring for acute spinal cord injury

T2 - a narrative review of current literature

AU - Tsehay, Yohannes

AU - Weber-Levine, Carly

AU - Kim, Timothy

AU - Chara, Alejandro

AU - Alomari, Safwan

AU - Awosika, Tolulope

AU - Liu, Ann

AU - Ehresman, Jeffrey

AU - Lehner, Kurt

AU - Hwang, Brian

AU - Hersh, Andrew M.

AU - Suk, Ian

AU - Curry, Eli

AU - Aghabaglou, Fariba

AU - Zeng, Yinuo

AU - Manbachi, Amir

AU - Theodore, Nicholas

PY - 2022/8

Y1 - 2022/8

N2 - Spinal cord injury (SCI) is a devastating condition that affects about 17,000 individuals every year in the United States, with approximately 294,000 people living with the ramifications of the initial injury. After the initial primary injury, SCI has a secondary phase during which the spinal cord sustains further injury due to ischemia, excitotoxicity, immune-mediated damage, mitochondrial dysfunction, apoptosis, and oxidative stress. The multifaceted injury progression process requires a sophisticated injury-monitoring technique for an accurate assessment of SCI patients. In this narrative review, we discuss SCI monitoring modalities, including pressure probes and catheters, micro dialysis, electrophysiologic measures, biomarkers, and imaging studies. The optimal next-generation injury monitoring setup should include multiple modalities and should integrate the data to produce a final simplified assessment of the injury and determine markers of intervention to improve patient outcomes.

AB - Spinal cord injury (SCI) is a devastating condition that affects about 17,000 individuals every year in the United States, with approximately 294,000 people living with the ramifications of the initial injury. After the initial primary injury, SCI has a secondary phase during which the spinal cord sustains further injury due to ischemia, excitotoxicity, immune-mediated damage, mitochondrial dysfunction, apoptosis, and oxidative stress. The multifaceted injury progression process requires a sophisticated injury-monitoring technique for an accurate assessment of SCI patients. In this narrative review, we discuss SCI monitoring modalities, including pressure probes and catheters, micro dialysis, electrophysiologic measures, biomarkers, and imaging studies. The optimal next-generation injury monitoring setup should include multiple modalities and should integrate the data to produce a final simplified assessment of the injury and determine markers of intervention to improve patient outcomes.

KW - Advanced monitoring for spinal cord injury

KW - Artificial intelligence

KW - Biomarkers

KW - Electrophysiology

KW - Imaging

KW - MRI

KW - Machine learning

KW - Spinal cord injury

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85129510472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85129510472&partnerID=8YFLogxK

U2 - 10.1016/j.spinee.2022.03.012

DO - 10.1016/j.spinee.2022.03.012

M3 - Review article

C2 - 35351667

AN - SCOPUS:85129510472

SN - 1529-9430

VL - 22

SP - 1372

EP - 1387

JO - Spine Journal

JF - Spine Journal

IS - 8

ER -

Advances in monitoring for acute spinal cord injury: a narrative review of current literature

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this